Anti-SSB antibody (2-408 aa) [4B10-E11-H11] (STJA0012878)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationUnconjugated
IsotypeIgG1
ImmunogenPurified recombinant human La Antigen protein fragments expressed in E.coli.
General Information
| Short Description | Mouse monoclonal anti-SSB (2-408 aa) for use in WB in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Mouse |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | 4B10-E11-H11 |
| Isotype | IgG1 |
| Conjugation | Unconjugated |
| Concentration | 2.65 mg/mL |
| Purification | Affinity Purified |
| Dilution Range | WB 1:500-1:1000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3. |
| Storage Instruction | Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
Target Information
| Gene Symbol | SSB |
| Gene ID | 6741 |
| Uniprot ID | LA_HUMAN |
| Immunogen | Purified recombinant human La Antigen protein fragments expressed in E.coli. |
| Immunogen Region | 2-408 aa |
Additional Info
| Post Translational Modifications | Phosphorylated. The phosphorylation sites are at the C-terminal part of the protein. The N-terminus is blocked. |
| Function | Binds to the 3' poly(U) terminus of nascent RNA polymerase III transcripts, protecting them from exonuclease digestion and facilitating their folding and maturation. In case of Coxsackievirus B3 infection, binds to the viral internal ribosome entry site (IRES) and stimulates the IRES-mediated translation. |
| Protein Name | Lupus La ProteinLa AutoantigenLa RibonucleoproteinSjoegren Syndrome Type B AntigenSs-B |
| Database Links | Reactome: R-HSA-73980Reactome: R-HSA-749476 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Lupus La Protein antibodyAnti-La Autoantigen antibodyAnti-La Ribonucleoprotein antibodyAnti-Sjoegren Syndrome Type B Antigen antibodyAnti-Ss-B antibodyAnti-SSB antibody |
Information sourced from Uniprot.org