Anti-SSB antibody (2-408 aa) [4B10-E11-H11] (STJA0012878)

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STJA0012878-100
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Short Description :Mouse monoclonal anti-SSB (2-408 aa) for use in WB in Human samples. Datasheet included with dilution recommendations, and related reagents.
Applications:WB
Host:Mouse
Reactivity:Human
Note:STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Clonality :Monoclonal
Clone ID :4B10-E11-H11
Isotype:IgG1
Conjugation:Unconjugated
Concentration:2.65 mg/mL
Purification:Affinity Purified
Dilution Range:WB 1:500-1:1000
Formulation:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.
Storage Instruction:Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles.
Gene Symbol:SSB
Gene ID:6741
Uniprot ID:LA_HUMAN
Immunogen:Purified recombinant human La Antigen protein fragments expressed in E.coli.
Immunogen Region:2-408 aa
Post Translational Modifications Phosphorylated. The phosphorylation sites are at the C-terminal part of the protein. The N-terminus is blocked.
Function Binds to the 3' poly(U) terminus of nascent RNA polymerase III transcripts, protecting them from exonuclease digestion and facilitating their folding and maturation. In case of Coxsackievirus B3 infection, binds to the viral internal ribosome entry site (IRES) and stimulates the IRES-mediated translation.
Protein Name Lupus La Protein
La Autoantigen
La Ribonucleoprotein
Sjoegren Syndrome Type B Antigen
Ss-B
Database Links Reactome: R-HSA-73980
Reactome: R-HSA-749476
Cellular Localisation Nucleus
Alternative Antibody Names Anti-Lupus La Protein antibody
Anti-La Autoantigen antibody
Anti-La Ribonucleoprotein antibody
Anti-Sjoegren Syndrome Type B Antigen antibody
Anti-Ss-B antibody
Anti-SSB antibody

Information sourced from Uniprot.org