| Host: | Rabbit |
| Applications: | WB/IHC-P/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:1000IHC-P:1:50-1:100ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | SRI |
| Gene ID: | 6717 |
| Uniprot ID: | SORCN_HUMAN |
| Immunogen Region: | 1-198 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-198 of human SRI (NP_003121.1). |
| Immunogen Sequence: | MAYPGHPGAGGGYYPGGYGG APGGPAFPGQTQDPLYGYFA AVAGQDGQIDADELQRCLTQ SGIAGGYKPFNLETCRLMVS MLDRDMSGTMGFNEFKELWA VLNGWRQHFISFDTDRSGTV DPQELQKALTTMGFRLSPQA VNSIAKRYSTNGKITFDDYI ACCVKLRALTDSFRRRDTAQ QGVVNFPYDDFIQCVMSV |
| Tissue Specificity | Detected in cardiac myocytes. |
| Function | Calcium-binding protein that modulates excitation-contraction coupling in the heart. Contributes to calcium homeostasis in the heart sarcoplasmic reticulum. Modulates the activity of RYR2 calcium channels. |
| Protein Name | Sorcin22 Kda ProteinCp-22Cp22V19 |
| Database Links | Reactome: R-HSA-2672351Reactome: R-HSA-418359Reactome: R-HSA-425561Reactome: R-HSA-5578775Reactome: R-HSA-936837 |
| Cellular Localisation | CytoplasmSarcoplasmic Reticulum MembranePeripheral Membrane ProteinCytoplasmic SideRelocates To The Sarcoplasmic Reticulum Membrane In Response To Elevated Calcium Levels |
| Alternative Antibody Names | Anti-Sorcin antibodyAnti-22 Kda Protein antibodyAnti-Cp-22 antibodyAnti-Cp22 antibodyAnti-V19 antibodyAnti-SRI antibody |
Information sourced from Uniprot.org
![Western blot analysis of lysates from wild type (WT) and SRI knockout (KO) HeLa cells, using [KO Validated] SRI Rabbit polyclonal antibody (STJ11100797) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 1s.](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/600x533/products/89733/358211/STJ11100797_1__02864.1713122535.jpg?c=1 "Western blot analysis of lysates from wild type (WT) and SRI knockout (KO) HeLa cells, using [KO Validated] SRI Rabbit polyclonal antibody (STJ11100797) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 1s.")
