| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-SPTLC2 (423-562) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
SPTLC2 |
| Gene ID: |
9517 |
| Uniprot ID: |
SPTC2_HUMAN |
| Immunogen Region: |
423-562 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 423-562 of human SPTLC2 (NP_004854.1). |
| Immunogen Sequence: |
MKCIMGQDGTSLGKECVQQL AENTRYFRRRLKEMGFIIYG NEDSPVVPLMLYMPAKIGAF GREMLKRNIGVVVVGFPATP IIESRARFCLSAAHTKEILD TALKEIDEVGDLLQLKYSRH RLVPLLDRPFDETTYEETED |
| Tissue Specificity | Widely expressed. |
| Function | Component of the serine palmitoyltransferase multisubunit enzyme (SPT) that catalyzes the initial and rate-limiting step in sphingolipid biosynthesis by condensing L-serine and activated acyl-CoA (most commonly palmitoyl-CoA) to form long-chain bases. The SPT complex is composed of SPTLC1, SPTLC2 or SPTLC3 and SPTSSA or SPTSSB. Within this complex, the heterodimer consisting of SPTLC1 and SPTLC2/SPTLC3 forms the catalytic core. The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference. The SPTLC1-SPTLC2-SPTSSA complex shows a strong preference for C16-CoA substrate, while the SPTLC1-SPTLC3-SPTSSA isozyme uses both C14-CoA and C16-CoA as substrates, with a slight preference for C14-CoA. The SPTLC1-SPTLC2-SPTSSB complex shows a strong preference for C18-CoA substrate, while the SPTLC1-SPTLC3-SPTSSB isozyme displays an ability to use a broader range of acyl-CoAs, without apparent preference. Crucial for adipogenesis. |
| Protein Name | Serine Palmitoyltransferase 2Long Chain Base Biosynthesis Protein 2Lcb 2Long Chain Base Biosynthesis Protein 2aLcb2aSerine-Palmitoyl-Coa Transferase 2Spt 2 |
| Database Links | Reactome: R-HSA-1660661 |
| Cellular Localisation | Endoplasmic Reticulum MembraneSingle-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Serine Palmitoyltransferase 2 antibodyAnti-Long Chain Base Biosynthesis Protein 2 antibodyAnti-Lcb 2 antibodyAnti-Long Chain Base Biosynthesis Protein 2a antibodyAnti-Lcb2a antibodyAnti-Serine-Palmitoyl-Coa Transferase 2 antibodyAnti-Spt 2 antibodyAnti-SPTLC2 antibodyAnti-KIAA0526 antibodyAnti-LCB2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
