| Host: | Mouse |
| Applications: | WB/IHC/ICC |
| Reactivity: | Bovine/Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: | Mouse monoclonal antibody anti-Alpha II Spectrin is suitable for use in Western Blot, Immunohistochemistry and Immunocytochemistry research applications. |
| Clonality: | Monoclonal |
| Clone ID: | 3D7 |
| Conjugation: | Unconjugated |
| Isotype: | IgG1 |
| Formulation: | 100 ul in PBS + 50% Glycerol and 5 mm Sodium Azide |
| Purification: | This antibody was protein g purified culture from supernatant. |
| Dilution Range: | WB 1:3000IHC 1:500-1:2000ICC 1:500-1:2000IP |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | SPTAN1 |
| Gene ID: | 6709 |
| Uniprot ID: | SPTN1_HUMAN |
| Immunogen: | Recombinant contstruct containing the 7th, 8th, 9th repeats of human alpha II spectrin. |
| Post Translational Modifications | Phosphorylation of Tyr-1176 decreases sensitivity to cleavage by calpain in vitro. |
| Function | Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane. |
| Protein Name | Spectrin Alpha Chain - Non-Erythrocytic 1Alpha-Ii SpectrinFodrin Alpha ChainSpectrin - Non-Erythroid Alpha Subunit |
| Database Links | Reactome: R-HSA-264870Reactome: R-HSA-373753Reactome: R-HSA-375165Reactome: R-HSA-445095Reactome: R-HSA-5673001Reactome: R-HSA-6798695Reactome: R-HSA-6807878Reactome: R-HSA-9013420Reactome: R-HSA-9013424Reactome: R-HSA-9662360Reactome: R-HSA-9662361 |
| Cellular Localisation | CytoplasmCytoskeletonCell CortexExpressed Along The Cell Membrane In Podocytes And Presumptive Tubule Cells During Glomerulogenesis And Is Expressed Along Lateral Cell Margins In Tubule Cells |
| Alternative Antibody Names | Anti-Spectrin Alpha Chain - Non-Erythrocytic 1 antibodyAnti-Alpha-Ii Spectrin antibodyAnti-Fodrin Alpha Chain antibodyAnti-Spectrin - Non-Erythroid Alpha Subunit antibodyAnti-SPTAN1 antibodyAnti-NEAS antibodyAnti-SPTA2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
