Anti-SPTAN1 antibody [3D7] (STJA0003570)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationUnconjugated
IsotypeIgG1
ImmunogenRecombinant contstruct containing the 7th, 8th, 9th repeats of human alpha II spectrin.
General Information
| Short Description | Mouse monoclonal anti-Alpha II Spectrin for use in WB, IHC and ICC in Bovine, Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC/ICC |
| Host | Mouse |
| Reactivity | Bovine/Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | 3D7 |
| Isotype | IgG1 |
| Conjugation | Unconjugated |
| Purification | This antibody was protein g purified culture from supernatant. |
| Dilution Range | WB 1:3000IHC 1:500-1:2000ICC 1:500-1:2000 |
| Formulation | 100 ul in PBS + 50% Glycerol and 5 mm Sodium Azide |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | SPTAN1 |
| Gene ID | 6709 |
| Uniprot ID | SPTN1_HUMAN |
| Immunogen | Recombinant contstruct containing the 7th, 8th, 9th repeats of human alpha II spectrin. |
Additional Info
| Post Translational Modifications | Phosphorylation of Tyr-1176 decreases sensitivity to cleavage by calpain in vitro. |
| Function | Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane. |
| Protein Name | Spectrin Alpha Chain - Non-Erythrocytic 1Alpha-Ii SpectrinFodrin Alpha ChainSpectrin - Non-Erythroid Alpha Subunit |
| Database Links | Reactome: R-HSA-264870Reactome: R-HSA-373753Reactome: R-HSA-375165Reactome: R-HSA-445095Reactome: R-HSA-5673001Reactome: R-HSA-6798695Reactome: R-HSA-6807878Reactome: R-HSA-9013420Reactome: R-HSA-9013424Reactome: R-HSA-9662360Reactome: R-HSA-9662361 |
| Cellular Localisation | CytoplasmCytoskeletonCell CortexExpressed Along The Cell Membrane In Podocytes And Presumptive Tubule Cells During Glomerulogenesis And Is Expressed Along Lateral Cell Margins In Tubule Cells |
| Alternative Antibody Names | Anti-Spectrin Alpha Chain - Non-Erythrocytic 1 antibodyAnti-Alpha-Ii Spectrin antibodyAnti-Fodrin Alpha Chain antibodyAnti-Spectrin - Non-Erythroid Alpha Subunit antibodyAnti-SPTAN1 antibodyAnti-NEAS antibodyAnti-SPTA2 antibody |
Information sourced from Uniprot.org