Anti-SOX10 antibody [SOX10/1074] (STJ16101855)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationUnconjugated
IsotypeIgG2bk
ImmunogenRecombinant fragment (155 Amino residues between aa 100-300) of human SOX10 protein
General Information
| Short Description | Mouse monoclonal anti-SOX10 for use in IHC-F and IHC-P in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC-F/IHC-P |
| Host | Mouse |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | SOX10/1074 |
| Isotype | IgG2bk |
| Conjugation | Unconjugated |
| Purification | Concentrate |
| Dilution Range | IHC-FIHC-P 1:200-1:400 |
| Formulation | Bioreactor Concentrate with 0.05% Azide |
| Storage Instruction | Store at 2-8°C for up to 1-year, upon receipt. |
Target Information
| Gene Symbol | SOX10 |
| Gene ID | 6663 |
| Uniprot ID | SOX10_HUMAN |
| Immunogen | Recombinant fragment (155 Amino residues between aa 100-300) of human SOX10 protein |
Additional Info
| Tissue Specificity | Expressed in fetal brain and in adult brain, heart, small intestine and colon. |
| Function | Transcription factor that plays a central role in developing and mature glia. Specifically activates expression of myelin genes, during oligodendrocyte (OL) maturation, such as DUSP15 and MYRF, thereby playing a central role in oligodendrocyte maturation and CNS myelination. Once induced, MYRF cooperates with SOX10 to implement the myelination program. Transcriptional activator of MITF, acting synergistically with PAX3. Transcriptional activator of MBP, via binding to the gene promoter. |
| Protein Name | Transcription Factor Sox-10 |
| Database Links | Reactome: R-HSA-9619665Reactome: R-HSA-9764302Reactome: R-HSA-9824585Reactome: R-HSA-9856649 |
| Cellular Localisation | CytoplasmNucleusMitochondrion Outer MembranePeripheral Membrane ProteinCytoplasmic Side |
| Alternative Antibody Names | Anti-Transcription Factor Sox-10 antibodyAnti-SOX10 antibody |
Information sourced from Uniprot.org