Anti-SOX10 antibody (350-450) [S5MR] (STJ11102345)

Name: Anti-SOX10 antibody (350-450) [S5MR] (STJ11102345)
SKU: STJ11102345
Availability: InStock

⇓ Datasheet ⇓ SDS

SPECIFICATIONS

ClonalityMonoclonal

HostRabbit

ConjugationUnconjugated

IsotypeIgG

STJ11102345

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Short Description	Rabbit monoclonal SOX10 (350-450) antibody for use in WB, IF, ICC and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents.
Applications	WB/IF/ICC/ELISA
Host	Rabbit
Reactivity	Human/Mouse/Rat
Note	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.

Clonality	Monoclonal
Clone ID	S5MR
Isotype	IgG
Conjugation	Unconjugated
Concentration	Lot specific
Purification	Affinity purification
Dilution Range	WB:1:1000-1:6000 IF/ICC:1:100-1:400 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements.
Formulation	PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH 7.3.
Storage Instruction	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol	SOX10
Gene ID	6663
Uniprot ID	SOX10_HUMAN
Immunogen Region	350-450
Immunogen Sequence	VDAKAQVKTETAGPQGPPHY TDQPSTSQIAYTSLSLPHYG SAFPSISRPQFDYSDHQPSG PYYGHSGQASGLYSAFSYMG PSQRPLYTAISDPSPSGPQS H
Specificity	A synthetic peptide corresponding to a sequence within amino acids 350-450 of human SOX10 (P56693).

Tissue Specificity	Expressed in fetal brain and in adult brain, heart, small intestine and colon.
Function	Transcription factor that plays a central role in developing and mature glia. Specifically activates expression of myelin genes, during oligodendrocyte (OL) maturation, such as DUSP15 and MYRF, thereby playing a central role in oligodendrocyte maturation and CNS myelination. Once induced, MYRF cooperates with SOX10 to implement the myelination program. Transcriptional activator of MITF, acting synergistically with PAX3. Transcriptional activator of MBP, via binding to the gene promoter.
Protein Name	Transcription Factor Sox-10
Database Links	Reactome: R-HSA-9619665 Reactome: R-HSA-9764302 Reactome: R-HSA-9824585 Reactome: R-HSA-9856649
Cellular Localisation	Cytoplasm Nucleus Mitochondrion Outer Membrane Peripheral Membrane Protein Cytoplasmic Side
Alternative Antibody Names	Anti-Transcription Factor Sox-10 antibody Anti-SOX10 antibody

Information sourced from Uniprot.org