| Short Description : | Rabbit monoclonal SOD2 (1-100) antibody for use in WB, IHC-P, IF, ICC and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/IHC-P/IF/ICC/ELISA |
| Host: | Rabbit |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Monoclonal |
| Clone ID : | S7MR |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | Lot specific |
| Purification: | Affinity purification |
| Dilution Range: | WB:1:2000-1:8000IHC-P:1:200-1:2000IF/ICC:1:200-1:800ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation: | PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH 7.3. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | SOD2 |
| Gene ID: | 6648 |
| Uniprot ID: | SODM_HUMAN |
| Immunogen Region: | 1-100 |
| Immunogen Sequence: | MLSRAVCGTSRQLAPVLGYL GSRQKHSLPDLPYDYGALEP HINAQIMQLHHSKHHAAYVN NLNVTEEKYQEALAKGDVTA QIALQPALKFNGGGHINHSI |
| Specificity: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human SOD2 (P04179). |
| Post Translational Modifications | Nitrated under oxidative stress. Nitration coupled with oxidation inhibits the catalytic activity. Acetylation at Lys-122 decreases enzymatic activity. Deacetylated by SIRT3 upon exposure to ionizing radiations or after long fasting. Polyubiquitinated.leading to proteasomal degradation. Deubiquitinated by USP36 which increases protein stability. |
| Function | Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems. |
| Protein Name | Superoxide Dismutase Mn - Mitochondrial |
| Database Links | Reactome: R-HSA-2151201Reactome: R-HSA-3299685Reactome: R-HSA-8862803Reactome: R-HSA-8950505Reactome: R-HSA-9615017Reactome: R-HSA-9841251 |
| Cellular Localisation | Mitochondrion Matrix |
| Alternative Antibody Names | Anti-Superoxide Dismutase Mn - Mitochondrial antibodyAnti-SOD2 antibody |
Information sourced from Uniprot.org
