Anti-SOD2 antibody (1-100) [S7MR] (STJ11101707)

Name: Anti-SOD2 antibody (1-100) [S7MR] (STJ11101707)
SKU: STJ11101707
Availability: InStock

⇓ Datasheet ⇓ SDS

SPECIFICATIONS

ClonalityMonoclonal

HostRabbit

ConjugationUnconjugated

IsotypeIgG

STJ11101707

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Short Description	Rabbit monoclonal SOD2 (1-100) antibody for use in WB, IHC-P, IF, ICC and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents.
Applications	WB/IHC-P/IF/ICC/ELISA
Host	Rabbit
Reactivity	Human/Mouse/Rat
Note	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.

Clonality	Monoclonal
Clone ID	S7MR
Isotype	IgG
Conjugation	Unconjugated
Concentration	Lot specific
Purification	Affinity purification
Dilution Range	WB:1:2000-1:8000 IHC-P:1:200-1:2000 IF/ICC:1:200-1:800 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements.
Formulation	PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH 7.3.
Storage Instruction	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol	SOD2
Gene ID	6648
Uniprot ID	SODM_HUMAN
Immunogen Region	1-100
Immunogen Sequence	MLSRAVCGTSRQLAPVLGYL GSRQKHSLPDLPYDYGALEP HINAQIMQLHHSKHHAAYVN NLNVTEEKYQEALAKGDVTA QIALQPALKFNGGGHINHSI
Specificity	A synthetic peptide corresponding to a sequence within amino acids 1-100 of human SOD2 (P04179).

Post Translational Modifications	Nitrated under oxidative stress. Nitration coupled with oxidation inhibits the catalytic activity. Acetylation at Lys-122 decreases enzymatic activity. Deacetylated by SIRT3 upon exposure to ionizing radiations or after long fasting. Polyubiquitinated.leading to proteasomal degradation. Deubiquitinated by USP36 which increases protein stability.
Function	Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.
Protein Name	Superoxide Dismutase Mn - Mitochondrial
Database Links	Reactome: R-HSA-2151201 Reactome: R-HSA-3299685 Reactome: R-HSA-8862803 Reactome: R-HSA-8950505 Reactome: R-HSA-9615017 Reactome: R-HSA-9841251
Cellular Localisation	Mitochondrion Matrix
Alternative Antibody Names	Anti-Superoxide Dismutase Mn - Mitochondrial antibody Anti-SOD2 antibody

Information sourced from Uniprot.org