![Anti-SOCS3 antibody [SO1] (STJ16100689)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/124x110/products/149406/346848/STJ16100689_1__77518.1681998985.jpg?c=1 "Anti-SOCS3 antibody [SO1] (STJ16100689)")
![Anti-SOCS3 antibody [SO1] (STJ16100689)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/1280x1280/products/149406/346848/STJ16100689_1__77518.1681998985.jpg?c=1 "Anti-SOCS3 antibody [SO1] (STJ16100689)")
| Host: | Mouse |
| Applications: | WB |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Mouse monoclonal antibody anti-SOCS3 is suitable for use in Western Blot research applications. |
| Clonality : | Monoclonal |
| Clone ID : | SO1 |
| Conjugation: | Unconjugated |
| Isotype: | IgG2b |
| Formulation: | Phosphate buffered saline (PBS) solution with 15 mM sodium azide |
| Concentration: | 1 mg/mL |
| Storage Instruction: | Store at 2-8°C upon receipt. |
| Gene Symbol: | SOCS3 |
| Gene ID: | 9021 |
| Uniprot ID: | SOCS3_HUMAN |
| Immunogen: | Full-length SOCS3 protein. |
| Tissue Specificity | Widely expressed with high expression in heart, placenta, skeletal muscle, peripheral blood leukocytes, fetal and adult lung, and fetal liver and kidney. Lower levels in thymus. |
| Post Translational Modifications | Phosphorylated on tyrosine residues after stimulation by the cytokines, IL-2, EPO or IGF1. |
| Function | SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS3 is involved in negative regulation of cytokines that signal through the JAK/STAT pathway. Inhibits cytokine signal transduction by binding to tyrosine kinase receptors including IL6ST/gp130, LIF, erythropoietin, insulin, IL12, GCSF and leptin receptors. Binding to JAK2 inhibits its kinase activity and regulates IL6 signaling. Suppresses fetal liver erythropoiesis. Regulates onset and maintenance of allergic responses mediated by T-helper type 2 cells. Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. |
| Protein Name | Suppressor Of Cytokine Signaling 3 Socs-3 Cytokine-Inducible Sh2 Protein 3 Cis-3 Stat-Induced Stat Inhibitor 3 Ssi-3 |
| Database Links | Reactome: R-HSA-1059683 Reactome: R-HSA-2586552 Reactome: R-HSA-6785807 Reactome: R-HSA-877300 Reactome: R-HSA-877312 Reactome: R-HSA-8849474 Reactome: R-HSA-8939242 Reactome: R-HSA-8951664 Reactome: R-HSA-909733 Reactome: R-HSA-912694 Reactome: R-HSA-9674555 Reactome: R-HSA-9705462 Reactome: R-HSA-982772 Reactome: R-HSA-983168 |
| Alternative Antibody Names | Anti-Suppressor Of Cytokine Signaling 3 antibody Anti-Socs-3 antibody Anti-Cytokine-Inducible Sh2 Protein 3 antibody Anti-Cis-3 antibody Anti-Stat-Induced Stat Inhibitor 3 antibody Anti-Ssi-3 antibody Anti-SOCS3 antibody Anti-CIS3 antibody Anti-SSI3 antibody |
Information sourced from Uniprot.org