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Anti-SOCS3 antibody [SO1] (STJ16100689)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationUnconjugated
IsotypeIgG2b
ImmunogenFull-length SOCS3 protein.
General Information
| Short Description | Mouse monoclonal anti-SOCS3 for use in WB in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Mouse |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | SO1 |
| Isotype | IgG2b |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Formulation | Phosphate buffered saline (PBS) solution with 15 mM sodium azide |
| Storage Instruction | Store at 2-8°C for up to 1-year, upon receipt. |
Target Information
| Gene Symbol | SOCS3 |
| Gene ID | 9021 |
| Uniprot ID | SOCS3_HUMAN |
| Immunogen | Full-length SOCS3 protein. |
Additional Info
| Tissue Specificity | Widely expressed with high expression in heart, placenta, skeletal muscle, peripheral blood leukocytes, fetal and adult lung, and fetal liver and kidney. Lower levels in thymus. |
| Post Translational Modifications | Phosphorylated on tyrosine residues after stimulation by the cytokines, IL-2, EPO or IGF1. |
| Function | SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS3 is involved in negative regulation of cytokines that signal through the JAK/STAT pathway. Inhibits cytokine signal transduction by binding to tyrosine kinase receptors including IL6ST/gp130, LIF, erythropoietin, insulin, IL12, GCSF and leptin receptors. Binding to JAK2 inhibits its kinase activity and regulates IL6 signaling. Suppresses fetal liver erythropoiesis. Regulates onset and maintenance of allergic responses mediated by T-helper type 2 cells. Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. |
| Protein Name | Suppressor Of Cytokine Signaling 3Socs-3Cytokine-Inducible Sh2 Protein 3Cis-3Stat-Induced Stat Inhibitor 3Ssi-3 |
| Database Links | Reactome: R-HSA-1059683Reactome: R-HSA-2586552Reactome: R-HSA-6785807Reactome: R-HSA-877300Reactome: R-HSA-877312Reactome: R-HSA-8849474Reactome: R-HSA-8939242Reactome: R-HSA-8951664Reactome: R-HSA-909733Reactome: R-HSA-912694Reactome: R-HSA-9674555Reactome: R-HSA-9705462Reactome: R-HSA-982772Reactome: R-HSA-983168 |
| Cellular Localisation | |
| Alternative Antibody Names | Anti-Suppressor Of Cytokine Signaling 3 antibodyAnti-Socs-3 antibodyAnti-Cytokine-Inducible Sh2 Protein 3 antibodyAnti-Cis-3 antibodyAnti-Stat-Induced Stat Inhibitor 3 antibodyAnti-Ssi-3 antibodyAnti-SOCS3 antibodyAnti-CIS3 antibodyAnti-SSI3 antibody |
Information sourced from Uniprot.org