| Host: |
Rabbit |
| Applications: |
WB/IHC/IF |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-SNW1 (300-536) is suitable for use in Western Blot, Immunohistochemistry and Immunofluorescence research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000IHC-P 1:50-1:100IF/ICC 1:50-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
SNW1 |
| Gene ID: |
22938 |
| Uniprot ID: |
SNW1_HUMAN |
| Immunogen Region: |
300-536 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 300-536 of human SNW1 (NP_036377.1). |
| Immunogen Sequence: |
EAVEMRAQVERKMAQKEKEK HEEKLREMAQKARERRAGIK THVEKEDGEARERDEIRHDR RKERQHDRNLSRAAPDKRSK LQRNENRDISEVIALGVPNP RTSNEVQYDQRLFNQSKGMD SGFAGGEDEIYNVYDQAWRG GKDMAQSIYRPSKNLDKDMY GDDLEARIKTNRFVPDKEFS GSDRRQRGREGPVQFEEDPF GLDKFLEEAKQHGGSKRPSD SSRPKEHEHEGKKRRKE |
| Function | Involved in pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). Required for the specific splicing of CDKN1A pre-mRNA.the function probably involves the recruitment of U2AF2 to the mRNA. May recruit PPIL1 to the spliceosome. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. Involved in transcriptional regulation. Modulates TGF-beta-mediated transcription via association with SMAD proteins, MYOD1-mediated transcription via association with PABPN1, RB1-mediated transcriptional repression, and retinoid-X receptor (RXR)- and vitamin D receptor (VDR)-dependent gene transcription in a cell line-specific manner probably involving coactivators NCOA1 and GRIP1. Is involved in NOTCH1-mediated transcriptional activation. Binds to multimerized forms of Notch intracellular domain (NICD) and is proposed to recruit transcriptional coactivators such as MAML1 to form an intermediate preactivation complex which associates with DNA-bound CBF-1/RBPJ to form a transcriptional activation complex by releasing SNW1 and redundant NOTCH1 NICD. (Microbial infection) Is recruited by HIV-1 Tat to Tat:P-TEFb:TAR RNA complexes and is involved in Tat transcription by recruitment of MYC, MEN1 and TRRAP to the HIV promoter. (Microbial infection) Proposed to be involved in transcriptional activation by EBV EBNA2 of CBF-1/RBPJ-repressed promoters. |
| Protein Name | Snw Domain-Containing Protein 1Nuclear Protein SkipNuclear Receptor Coactivator Ncoa-62Ski-Interacting Protein |
| Database Links | Reactome: R-HSA-1912408Reactome: R-HSA-210744Reactome: R-HSA-2122947Reactome: R-HSA-2173795Reactome: R-HSA-2644606Reactome: R-HSA-2894862Reactome: R-HSA-350054Reactome: R-HSA-72163Reactome: R-HSA-8941856Reactome: R-HSA-9013508Reactome: R-HSA-9013695Reactome: R-HSA-9793380 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Snw Domain-Containing Protein 1 antibodyAnti-Nuclear Protein Skip antibodyAnti-Nuclear Receptor Coactivator Ncoa-62 antibodyAnti-Ski-Interacting Protein antibodyAnti-SNW1 antibodyAnti-SKIIP antibodyAnti-SKIP antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
