| Post Translational Modifications | Methylated on arginine residues by PRMT5 and PRMT7.probable asymmetric dimethylation which is required for assembly and biogenesis of snRNPs. |
| Function | Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs. May act as a charged protein scaffold to promote snRNP assembly or strengthen snRNP-snRNP interactions through non-specific electrostatic contacts with RNA. |
| Protein Name | Small Nuclear Ribonucleoprotein Sm D1Sm-D1Sm-D AutoantigenSnrnp Core Protein D1 |
| Database Links | Reactome: R-HSA-191859Reactome: R-HSA-72163Reactome: R-HSA-72165Reactome: R-HSA-9754678 |
| Cellular Localisation | CytoplasmCytosolNucleusSmn-Mediated Assembly Into Core Snrnps Occurs In The Cytosol Before Smn-Mediated Transport To The Nucleus To Be Included In Spliceosomes |
| Alternative Antibody Names | Anti-Small Nuclear Ribonucleoprotein Sm D1 antibodyAnti-Sm-D1 antibodyAnti-Sm-D Autoantigen antibodyAnti-Snrnp Core Protein D1 antibodyAnti-SNRPD1 antibody |
Information sourced from Uniprot.org
![Immunofluorescence analysis of L929 cells using [KO Validated] SEC61B Rabbit polyclonal antibody (STJ118233) at dilution of 1:100. Blue: DAPI for nuclear staining.](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/600x533/products/97123/380111/STJ118233_1__50989.1713148036.jpg?c=1 "Immunofluorescence analysis of L929 cells using [KO Validated] SEC61B Rabbit polyclonal antibody (STJ118233) at dilution of 1:100. Blue: DAPI for nuclear staining.")
