Anti-SNRPA antibody (1-282) (STJ28493)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal SNRPA (1-282) antibody for use in WB, IHC-P, IF, ICC and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-P/IF/ICC/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000IHC-P:1:50-1:200IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | SNRPA |
| Gene ID | 6626 |
| Uniprot ID | SNRPA_HUMAN |
| Immunogen Region | 1-282 |
| Immunogen Sequence | MAVPETRPNHTIYINNLNEK IKKDELKKSLYAIFSQFGQI LDILVSRSLKMRGQAFVIFK EVSSATNALRSMQGFPFYDK PMRIQYAKTDSDIIAKMKGT FVERDRKREKRKPKSQETPA TKKAVQGGGATPVVGAVQGP VPGMPPMTQAPRIMHHMPGQ PPYMPPPGMIPPPGLAPGQI PPGAMPPQQLMPGQMPPAQP LSENPPNHILFLTNLPEETN ELMLSMLFNQFPGFKEVRL |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1-282 of human U1A/U1A/SNRPA (NP_004587.1). |
Additional Info
| Function | Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. U1 snRNP is the first snRNP to interact with pre-mRNA. This interaction is required for the subsequent binding of U2 snRNP and the U4/U6/U5 tri-snRNP. SNRPA binds stem loop II of U1 snRNA. In a snRNP-free form (SF-A) may be involved in coupled pre-mRNA splicing and polyadenylation process. May bind preferentially to the 5'-UGCAC-3' motif on RNAs. |
| Protein Name | U1 Small Nuclear Ribonucleoprotein AU1 Snrnp AU1-AU1a |
| Database Links | Reactome: R-HSA-72163 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-U1 Small Nuclear Ribonucleoprotein A antibodyAnti-U1 Snrnp A antibodyAnti-U1-A antibodyAnti-U1a antibodyAnti-SNRPA antibody |
Information sourced from Uniprot.org