• Western blot analysis of HeLa, using SNRNP70 rabbit polyclonal antibody (STJ116986) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% non-fat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 30s.

Anti-SNRNP70 antibody (1-180) (STJ116986)

SKU:
STJ116986

£112.50 - £522.50
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Host: Rabbit
Applications: WB
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-SNRNP70 (1-180) is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: SNRNP70
Gene ID: 6625
Uniprot ID: RU17_HUMAN
Immunogen Region: 1-180
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-180 of human SNRNP70 (NP_003080.2).
Immunogen Sequence: MTQFLPPNLLALFAPRDPIP YLPPLEKLPHEKHHNQPYCG IAPYIREFEDPRDAPPPTRA ETREERMERKRREKIERRQQ EVETELKMWDPHNDPNAQGD AFKTLFVARVNYDTTESKLR REFEVYGPIKRIHMVYSKRS GKPRGYAFIEYEHERDMHSA YKHADGKKIDGRRVLVDVER
Post Translational Modifications The N-terminus is blocked. Extensively phosphorylated on serine residues in the C-terminal region.
Function Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. SNRNP70 binds to the loop I region of U1-snRNA. Isoform 3: Truncated isoforms that lack the RRM domain cannot bind U1-snRNA. Isoform 4: Truncated isoforms that lack the RRM domain cannot bind U1-snRNA.
Protein Name U1 Small Nuclear Ribonucleoprotein 70 Kda
U1 Snrnp 70 Kda
U1-70k
Snrnp70
Database Links Reactome: R-HSA-72163
Cellular Localisation Nucleus Speckle
Nucleus
Nucleoplasm
Colocalizes With Scnm1 And Luc7l2 In Nuclear Speckles
Alternative Antibody Names Anti-U1 Small Nuclear Ribonucleoprotein 70 Kda antibody
Anti-U1 Snrnp 70 Kda antibody
Anti-U1-70k antibody
Anti-Snrnp70 antibody
Anti-SNRNP70 antibody
Anti-RNPU1Z antibody
Anti-RPU1 antibody
Anti-SNRP70 antibody
Anti-U1AP1 antibody

Information sourced from Uniprot.org

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