• Immunohistochemistry analysis of paraffin-embedded rat brain using gamma-Synuclein Rabbit monoclonal antibody (STJ11101831) at dilution of 1:100 (40x lens). Perform microwave antigen retrieval with 10 mM PBS buffer pH 7. 2 before commencing with immunohistochemistry staining protocol.
  • Western blot analysis of extracts of various cell lines, using gamma-Synuclein Rabbit monoclonal antibody (STJ11101831) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 3min.

Anti-SNCG antibody (48-127) [S1MR] (STJ11101831)

SKU:
STJ11101831

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Host: Rabbit
Applications: WB/IHC
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit monoclonal antibody anti-gamma Synuclein (48-127) is suitable for use in Western Blot and Immunohistochemistry research applications.
Clonality: Monoclonal
Clone ID: S1MR
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:1000 IHC-P 1:50-1:200
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: SNCG
Gene ID: 6623
Uniprot ID: SYUG_HUMAN
Immunogen Region: 48-127
Immunogen: A synthetic peptide corresponding to a sequence within amino acids 48-127 of human gamma-Synuclein (O76070).
Immunogen Sequence: VVQSVTSVAEKTKEQANAVS EAVVSSVNTVATKTVEEAEN IAVTSGVVRKEDLRPSAPQQ EGEASKEKEEVAEEAQSGGD
Tissue Specificity Highly expressed in brain, particularly in the substantia nigra. Also expressed in the corpus callosum, heart, skeletal muscle, ovary, testis, colon and spleen. Weak expression in pancreas, kidney and lung.
Post Translational Modifications Phosphorylated. Phosphorylation by GRK5 appears to occur on residues distinct from the residue phosphorylated by other kinases.
Function Plays a role in neurofilament network integrity. May be involved in modulating axonal architecture during development and in the adult. In vitro, increases the susceptibility of neurofilament-H to calcium-dependent proteases. May also function in modulating the keratin network in skin. Activates the MAPK and Elk-1 signal transduction pathway.
Protein Name Gamma-Synuclein
Breast Cancer-Specific Gene 1 Protein
Persyn
Synoretin
Sr
Cellular Localisation Cytoplasm
Perinuclear Region
Cytoskeleton
Microtubule Organizing Center
Centrosome
Spindle
Associated With Centrosomes In Several Interphase Cells
In Mitotic Cells
Localized To The Poles Of The Spindle
Alternative Antibody Names Anti-Gamma-Synuclein antibody
Anti-Breast Cancer-Specific Gene 1 Protein antibody
Anti-Persyn antibody
Anti-Synoretin antibody
Anti-Sr antibody
Anti-SNCG antibody
Anti-BCSG1 antibody
Anti-PERSYN antibody
Anti-PRSN antibody

Information sourced from Uniprot.org

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