Anti-SNCG antibody (48-127) [S1MR] (STJ11101831)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit monoclonal gamma Synuclein (48-127) antibody for use in WB, IHC-P and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-P/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | S1MR |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:1000 IHC-P:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | SNCG |
| Gene ID | 6623 |
| Uniprot ID | SYUG_HUMAN |
| Immunogen Region | 48-127 |
| Immunogen Sequence | VVQSVTSVAEKTKEQANAVS EAVVSSVNTVATKTVEEAEN IAVTSGVVRKEDLRPSAPQQ EGEASKEKEEVAEEAQSGGD |
| Specificity | A synthetic peptide corresponding to a sequence within amino acids 48-127 of human gamma-Synuclein (O76070). |
Additional Info
| Tissue Specificity | Highly expressed in brain, particularly in the substantia nigra. Also expressed in the corpus callosum, heart, skeletal muscle, ovary, testis, colon and spleen. Weak expression in pancreas, kidney and lung. |
| Post Translational Modifications | Phosphorylated. Phosphorylation by GRK5 appears to occur on residues distinct from the residue phosphorylated by other kinases. |
| Function | Plays a role in neurofilament network integrity. May be involved in modulating axonal architecture during development and in the adult. In vitro, increases the susceptibility of neurofilament-H to calcium-dependent proteases. May also function in modulating the keratin network in skin. Activates the MAPK and Elk-1 signal transduction pathway. |
| Protein Name | Gamma-SynucleinBreast Cancer-Specific Gene 1 ProteinPersynSynoretinSr |
| Database Links | |
| Cellular Localisation | CytoplasmPerinuclear RegionCytoskeletonMicrotubule Organizing CenterCentrosomeSpindleAssociated With Centrosomes In Several Interphase CellsIn Mitotic CellsLocalized To The Poles Of The Spindle |
| Alternative Antibody Names | Anti-Gamma-Synuclein antibodyAnti-Breast Cancer-Specific Gene 1 Protein antibodyAnti-Persyn antibodyAnti-Synoretin antibodyAnti-Sr antibodyAnti-SNCG antibodyAnti-BCSG1 antibodyAnti-PERSYN antibodyAnti-PRSN antibody |
Information sourced from Uniprot.org