| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Nonsense-mediated mRNA decay factor SMG8 is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
SMG8 |
| Gene ID: |
55181 |
| Uniprot ID: |
SMG8_HUMAN |
| Specificity: |
This antibody detects endogenous levels of SMG8 at Human, Mouse |
| Immunogen: |
Synthesized peptide derived from human SMG8 |
| Function | Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Is recruited by release factors to stalled ribosomes together with SMG1 and SMG9 (forming the SMG1C protein kinase complex) and, in the SMG1C complex, is required to mediate the recruitment of SMG1 to the ribosome:SURF complex and to suppress SMG1 kinase activity until the ribosome:SURF complex locates the exon junction complex (EJC). Acts as a regulator of kinase activity. |
| Protein Name | Nonsense-Mediated Mrna Decay Factor Smg8Amplified In Breast Cancer Gene 2 ProteinProtein Smg-8 Homolog |
| Database Links | Reactome: R-HSA-975957 |
| Alternative Antibody Names | Anti-Nonsense-Mediated Mrna Decay Factor Smg8 antibodyAnti-Amplified In Breast Cancer Gene 2 Protein antibodyAnti-Protein Smg-8 Homolog antibodyAnti-SMG8 antibodyAnti-ABC2 antibodyAnti-C17orf71 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
