Anti-SMG8 antibody (STJA0009034)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from human SMG8
General Information
| Short Description | Rabbit polyclonal anti-Nonsense-mediated mRNA decay factor SMG8 for use in WB in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | SMG8 |
| Gene ID | 55181 |
| Uniprot ID | SMG8_HUMAN |
| Immunogen | Synthesized peptide derived from human SMG8 |
| Specificity | This antibody detects endogenous levels of SMG8 at Human, Mouse |
Additional Info
| Function | Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Is recruited by release factors to stalled ribosomes together with SMG1 and SMG9 (forming the SMG1C protein kinase complex) and, in the SMG1C complex, is required to mediate the recruitment of SMG1 to the ribosome:SURF complex and to suppress SMG1 kinase activity until the ribosome:SURF complex locates the exon junction complex (EJC). Acts as a regulator of kinase activity. |
| Protein Name | Nonsense-Mediated Mrna Decay Factor Smg8Amplified In Breast Cancer Gene 2 ProteinProtein Smg-8 Homolog |
| Database Links | Reactome: R-HSA-975957 |
| Cellular Localisation | |
| Alternative Antibody Names | Anti-Nonsense-Mediated Mrna Decay Factor Smg8 antibodyAnti-Amplified In Breast Cancer Gene 2 Protein antibodyAnti-Protein Smg-8 Homolog antibodyAnti-SMG8 antibodyAnti-ABC2 antibodyAnti-C17orf71 antibody |
Information sourced from Uniprot.org