| Host: |
Rabbit |
| Applications: |
WB/IF |
| Reactivity: |
Human/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-SMCHD1 (1756-2005) is suitable for use in Western Blot and Immunofluorescence research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000IF/ICC 1:50-1:100 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
SMCHD1 |
| Gene ID: |
23347 |
| Uniprot ID: |
SMHD1_HUMAN |
| Immunogen Region: |
1756-2005 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1756-2005 of human SMCHD1 (NP_056110.2). |
| Immunogen Sequence: |
TTDAARRIYDETQGRQQVLP LDSIYKKTLPDWKRSLPHFR NGKLYFKPIGDPVFARDLLT FPDNVEHCETVFGMLLGDTI ILDNLDAANHYRKEVVKITH CPTLLTRDGDRIRSNGKFGG LQNKAPPMDKLRGMVFGAPV PKQCLILGEQIDLLQQYRSA VCKLDSVNKDLNSQLEYLRT PDMRKKKQELDEHEKNLKLI EEKLGMTPIRKCNDSLRHSP KVETTDCPVPPKRMRREAT |
| Post Translational Modifications | Sumoylated with SUMO1. |
| Function | Non-canonical member of the structural maintenance of chromosomes (SMC) protein family that plays a key role in epigenetic silencing by regulating chromatin architecture. Promotes heterochromatin formation in both autosomes and chromosome X, probably by mediating the merge of chromatin compartments. Plays a key role in chromosome X inactivation in females by promoting the spreading of heterochromatin. Recruited to inactivated chromosome X by Xist RNA and acts by mediating the merge of chromatin compartments: promotes random chromatin interactions that span the boundaries of existing structures, leading to create a compartment-less architecture typical of inactivated chromosome X. Required to facilitate Xist RNA spreading. Also required for silencing of a subset of clustered autosomal loci in somatic cells, such as the DUX4 locus. Has ATPase activity.may participate in structural manipulation of chromatin in an ATP-dependent manner as part of its role in gene expression regulation. Also plays a role in DNA repair: localizes to sites of DNA double-strand breaks in response to DNA damage to promote the repair of DNA double-strand breaks. Acts by promoting non-homologous end joining (NHEJ) and inhibiting homologous recombination (HR) repair. |
| Protein Name | Structural Maintenance Of Chromosomes Flexible Hinge Domain-Containing Protein 1Smc Hinge Domain-Containing Protein 1 |
| Cellular Localisation | ChromosomeRecruited To Inactivated Chromosome X In Females By Xist RnaLocalizes At Sites Of Dna Damage At Double-Strand Breaks (Dsbs) |
| Alternative Antibody Names | Anti-Structural Maintenance Of Chromosomes Flexible Hinge Domain-Containing Protein 1 antibodyAnti-Smc Hinge Domain-Containing Protein 1 antibodyAnti-SMCHD1 antibodyAnti-KIAA0650 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
