Anti-SMARCAD1 antibody (1-300) (STJ28413)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal SMARCAD1 (1-300) antibody for use in WB, IF, ICC and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IF/ICC/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000IF/ICC:1:50-1:100ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | SMARCAD1 |
| Gene ID | 56916 |
| Uniprot ID | SMRCD_HUMAN |
| Immunogen Region | 1-300 |
| Immunogen Sequence | MNLFNLDRFRFEKRNKIEEA PEATPQPSQPGPSSPISLSA EEENAEGEVSRANTPDSDIT EKTEDSSVPETPDNERKASI SYFKNQRGIQYIDLSSDSED VVSPNCSNTVQEKTFNKDTV IIVSEPSEDEESQGLPTMAR RNDDISELEDLSELEDLKDA KLQTLKELFPQRSDNDLLKL IESTSTMDGAIAAALLMFGD AGGGPRKRKLSSSSEPYEED EFNDDQSIKKTRLDHGEES |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human SMARCAD1 (NP_001121901.1). |
Additional Info
| Tissue Specificity | Isoform 1 is expressed ubiquitously. Isoform 3 is expressed mainly in skin and esophagus. Expressed in fibroblasts and keratinocytes (at protein level). |
| Function | DNA helicase that possesses intrinsic ATP-dependent nucleosome-remodeling activity and is both required for DNA repair and heterochromatin organization. Promotes DNA end resection of double-strand breaks (DSBs) following DNA damage: probably acts by weakening histone DNA interactions in nucleosomes flanking DSBs. Required for the restoration of heterochromatin organization after replication. Acts at replication sites to facilitate the maintenance of heterochromatin by directing H3 and H4 histones deacetylation, H3 'Lys-9' trimethylation (H3K9me3) and restoration of silencing. |
| Protein Name | Swi/Snf-Related Matrix-Associated Actin-Dependent Regulator Of Chromatin Subfamily A Containing Dead/H Box 1Smarcad1Atp-Dependent Helicase 1Hhel1 |
| Database Links | |
| Cellular Localisation | NucleusChromosomeColocalizes With Pcna At Replication Forks During S PhaseRecruited To Double-Strand Breaks (Dsbs) Sites Of Dna Damage |
| Alternative Antibody Names | Anti-Swi/Snf-Related Matrix-Associated Actin-Dependent Regulator Of Chromatin Subfamily A Containing Dead/H Box 1 antibodyAnti-Smarcad1 antibodyAnti-Atp-Dependent Helicase 1 antibodyAnti-Hhel1 antibodyAnti-SMARCAD1 antibodyAnti-KIAA1122 antibody |
Information sourced from Uniprot.org