Anti-SLCO1B3 antibody (STJA0009732)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from human SLCO1B3
General Information
| Short Description | Rabbit polyclonal anti-Solute carrier organic anion transporter family member 1B3 for use in WB in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | SLCO1B3 |
| Gene ID | 28234 |
| Uniprot ID | SO1B3_HUMAN |
| Immunogen | Synthesized peptide derived from human SLCO1B3 |
| Specificity | This antibody detects endogenous levels of SLCO1B3 at Human |
Additional Info
| Post Translational Modifications | N-glycosylated. |
| Function | Mediates the Na(+)-independent uptake of organic anions. Shows broad substrate specificity, can transport both organic anions such as bile acid taurocholate (cholyltaurine) and conjugated steroids (17-beta-glucuronosyl estradiol, dehydroepiandrosterone sulfate (DHEAS), and estrone 3-sulfate), as well as eicosanoid leukotriene C4, prostaglandin E2 and L-thyroxine (T4). Hydrogencarbonate/HCO3(-) acts as the probable counteranion that exchanges for organic anions. Shows a pH-sensitive substrate specificity towards sulfated steroids, taurocholate and T4 which may be ascribed to the protonation state of the binding site and leads to a stimulation of substrate transport in an acidic microenvironment. Involved in the clearance of bile acids and organic anions from the liver. Can take up bilirubin glucuronides from plasma into the liver, contributing to the detoxification-enhancing liver-blood shuttling loop. Transports coproporphyrin I and III, by-products of heme synthesis, and may be involved in their hepatic disposition. May contribute to regulate the transport of organic compounds in testes across the blood-testis-barrier (Probable). Can transport HMG-CoA reductase inhibitors (also known as statins) such as pitavastatin, a clinically important class of hypolipidemic drugs. May play an important role in plasma and tissue distribution of the structurally diverse chemotherapeutic drugs methotrexate and paclitaxel. May also transport antihypertension agents, such as the angiotensin-converting enzyme (ACE) inhibitor prodrug enalapril, and the highly selective angiotensin II AT1-receptor antagonist valsartan, in the liver. |
| Protein Name | Solute Carrier Organic Anion Transporter Family Member 1b3Liver-Specific Organic Anion Transporter 2Lst-2Oatp1b3Organic Anion Transporter 8Organic Anion-Transporting Polypeptide 8Oatp-8Solute Carrier Family 21 Member 8 |
| Database Links | Reactome: R-HSA-159418Reactome: R-HSA-189483Reactome: R-HSA-5619058Reactome: R-HSA-879518Reactome: R-HSA-9754706 |
| Cellular Localisation | Basolateral Cell MembraneMulti-Pass Membrane ProteinBasal Cell MembraneLocalized To The Basolateral Membrane Of HepatocytesLocalized To The Basal Membrane Of Sertoli Cells |
| Alternative Antibody Names | Anti-Solute Carrier Organic Anion Transporter Family Member 1b3 antibodyAnti-Liver-Specific Organic Anion Transporter 2 antibodyAnti-Lst-2 antibodyAnti-Oatp1b3 antibodyAnti-Organic Anion Transporter 8 antibodyAnti-Organic Anion-Transporting Polypeptide 8 antibodyAnti-Oatp-8 antibodyAnti-Solute Carrier Family 21 Member 8 antibodyAnti-SLCO1B3 antibodyAnti-LST2 antibodyAnti-OATP1B3 antibodyAnti-OATP8 antibodyAnti-SLC21A8 antibody |
Information sourced from Uniprot.org