| Host: | Rabbit |
| Applications: | WB |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Solute carrier organic anion transporter family member 1B3 is suitable for use in Western Blot research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-2000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | SLCO1B3 |
| Gene ID: | 28234 |
| Uniprot ID: | SO1B3_HUMAN |
| Specificity: | This antibody detects endogenous levels of SLCO1B3 at Human |
| Immunogen: | Synthesized peptide derived from human SLCO1B3 |
| Post Translational Modifications | N-glycosylated. |
| Function | Mediates the Na(+)-independent uptake of organic anions. Shows broad substrate specificity, can transport both organic anions such as bile acid taurocholate (cholyltaurine) and conjugated steroids (17-beta-glucuronosyl estradiol, dehydroepiandrosterone sulfate (DHEAS), and estrone 3-sulfate), as well as eicosanoid leukotriene C4, prostaglandin E2 and L-thyroxine (T4). Hydrogencarbonate/HCO3(-) acts as the probable counteranion that exchanges for organic anions. Shows a pH-sensitive substrate specificity towards sulfated steroids, taurocholate and T4 which may be ascribed to the protonation state of the binding site and leads to a stimulation of substrate transport in an acidic microenvironment. Involved in the clearance of bile acids and organic anions from the liver. Can take up bilirubin glucuronides from plasma into the liver, contributing to the detoxification-enhancing liver-blood shuttling loop. Transports coproporphyrin I and III, by-products of heme synthesis, and may be involved in their hepatic disposition. May contribute to regulate the transport of organic compounds in testes across the blood-testis-barrier (Probable). Can transport HMG-CoA reductase inhibitors (also known as statins) such as pitavastatin, a clinically important class of hypolipidemic drugs. May play an important role in plasma and tissue distribution of the structurally diverse chemotherapeutic drugs methotrexate and paclitaxel. May also transport antihypertension agents, such as the angiotensin-converting enzyme (ACE) inhibitor prodrug enalapril, and the highly selective angiotensin II AT1-receptor antagonist valsartan, in the liver. |
| Protein Name | Solute Carrier Organic Anion Transporter Family Member 1b3 Liver-Specific Organic Anion Transporter 2 Lst-2 Oatp1b3 Organic Anion Transporter 8 Organic Anion-Transporting Polypeptide 8 Oatp-8 Solute Carrier Family 21 Member 8 |
| Database Links | Reactome: R-HSA-159418 Reactome: R-HSA-189483 Reactome: R-HSA-5619058 Reactome: R-HSA-879518 Reactome: R-HSA-9754706 |
| Cellular Localisation | Basolateral Cell Membrane Multi-Pass Membrane Protein Basal Cell Membrane Localized To The Basolateral Membrane Of Hepatocytes Localized To The Basal Membrane Of Sertoli Cells |
| Alternative Antibody Names | Anti-Solute Carrier Organic Anion Transporter Family Member 1b3 antibody Anti-Liver-Specific Organic Anion Transporter 2 antibody Anti-Lst-2 antibody Anti-Oatp1b3 antibody Anti-Organic Anion Transporter 8 antibody Anti-Organic Anion-Transporting Polypeptide 8 antibody Anti-Oatp-8 antibody Anti-Solute Carrier Family 21 Member 8 antibody Anti-SLCO1B3 antibody Anti-LST2 antibody Anti-OATP1B3 antibody Anti-OATP8 antibody Anti-SLC21A8 antibody |
Information sourced from Uniprot.org