Anti-SLC9B2 antibody (STJA0009229)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from human NHEDC2
General Information
| Short Description | Rabbit polyclonal anti-Sodium/hydrogen exchanger 9B2/H+ exchanger NHA2/H+ exchanger-like domain-containing protein 2 for use in WB in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | SLC9B2 |
| Gene ID | 133308 |
| Uniprot ID | SL9B2_HUMAN |
| Immunogen | Synthesized peptide derived from human NHEDC2 |
| Specificity | This antibody detects endogenous levels of NHEDC2 at Human, Mouse |
Additional Info
| Function | Electroneutral Na(+) Li(+)/H(+) antiporter that extrudes Na(+) or Li(+) in exchange for external protons across the membrane. Uses the proton gradient/membrane potential to extrude sodium. Contributes to the regulation of intracellular pH and sodium homeostasis. Also able to mediate Na(+)/Li(+) antiporter activity in kidney. May play a physiological role in renal tubular function and blood pressure homeostasis. Plays an important role for insulin secretion and clathrin-mediated endocytosis in beta-cells. Involved in sperm motility and fertility. It is controversial whether SLC9B2 plays a role in osteoclast differentiation or not. |
| Protein Name | Sodium/Hydrogen Exchanger 9b2Na(+/H(+ Exchanger Nha2Na(+/H(+ Exchanger-Like Domain-Containing Protein 2Nhe Domain-Containing Protein 2Sodium/Hydrogen Exchanger-Like Domain-Containing Protein 2Solute Carrier Family 9 Subfamily B Member 2 |
| Database Links | Reactome: R-HSA-2672351 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinMitochondrion MembraneEndosome MembraneRecycling Endosome MembraneCytoplasmic VesicleSecretory VesicleSynaptic Vesicle MembraneCell ProjectionCiliumFlagellum MembraneBasolateral Cell MembraneApical Cell MembraneStrong Colocalization With Lamp1 And Tcirg1 In OsteoclastsIn Beta-Cells Colocalizes With Rab4a And SypLocalizes To The Basolateral Membrane Of Polarized Osteoclasts |
| Alternative Antibody Names | Anti-Sodium/Hydrogen Exchanger 9b2 antibodyAnti-Na(+/H(+ Exchanger Nha2 antibodyAnti-Na(+/H(+ Exchanger-Like Domain-Containing Protein 2 antibodyAnti-Nhe Domain-Containing Protein 2 antibodyAnti-Sodium/Hydrogen Exchanger-Like Domain-Containing Protein 2 antibodyAnti-Solute Carrier Family 9 Subfamily B Member 2 antibodyAnti-SLC9B2 antibodyAnti-NHA2 antibodyAnti-NHEDC2 antibody |
Information sourced from Uniprot.org