| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Sodium/hydrogen exchanger 9B2/H+ exchanger NHA2/H+ exchanger-like domain-containing protein 2 is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
SLC9B2 |
| Gene ID: |
133308 |
| Uniprot ID: |
SL9B2_HUMAN |
| Specificity: |
This antibody detects endogenous levels of NHEDC2 at Human, Mouse |
| Immunogen: |
Synthesized peptide derived from human NHEDC2 |
| Function | Electroneutral Na(+) Li(+)/H(+) antiporter that extrudes Na(+) or Li(+) in exchange for external protons across the membrane. Uses the proton gradient/membrane potential to extrude sodium. Contributes to the regulation of intracellular pH and sodium homeostasis. Also able to mediate Na(+)/Li(+) antiporter activity in kidney. May play a physiological role in renal tubular function and blood pressure homeostasis. Plays an important role for insulin secretion and clathrin-mediated endocytosis in beta-cells. Involved in sperm motility and fertility. It is controversial whether SLC9B2 plays a role in osteoclast differentiation or not. |
| Protein Name | Sodium/Hydrogen Exchanger 9b2Na(+/H(+ Exchanger Nha2Na(+/H(+ Exchanger-Like Domain-Containing Protein 2Nhe Domain-Containing Protein 2Sodium/Hydrogen Exchanger-Like Domain-Containing Protein 2Solute Carrier Family 9 Subfamily B Member 2 |
| Database Links | Reactome: R-HSA-2672351 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinMitochondrion MembraneEndosome MembraneRecycling Endosome MembraneCytoplasmic VesicleSecretory VesicleSynaptic Vesicle MembraneCell ProjectionCiliumFlagellum MembraneBasolateral Cell MembraneApical Cell MembraneStrong Colocalization With Lamp1 And Tcirg1 In OsteoclastsIn Beta-Cells Colocalizes With Rab4a And SypLocalizes To The Basolateral Membrane Of Polarized Osteoclasts |
| Alternative Antibody Names | Anti-Sodium/Hydrogen Exchanger 9b2 antibodyAnti-Na(+/H(+ Exchanger Nha2 antibodyAnti-Na(+/H(+ Exchanger-Like Domain-Containing Protein 2 antibodyAnti-Nhe Domain-Containing Protein 2 antibodyAnti-Sodium/Hydrogen Exchanger-Like Domain-Containing Protein 2 antibodyAnti-Solute Carrier Family 9 Subfamily B Member 2 antibodyAnti-SLC9B2 antibodyAnti-NHA2 antibodyAnti-NHEDC2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
