| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-SLC9A6 (542-701) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
SLC9A6 |
| Gene ID: |
10479 |
| Uniprot ID: |
SL9A6_HUMAN |
| Immunogen Region: |
542-701 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 542-701 of human SLC9A6 (NP_001036002.1). |
| Immunogen Sequence: |
VDSDQEHLGVPENERRTTKA ESAWLFRMWYNFDHNYLKPL LTHSGPPLTTTLPACCGPIA RCLTSPQAYENQEQLKDDDS DLILNDGDISLTYGDSTVNT EPATSSAPRRFMGNSSEDAL DRELAFGDHELVIRGTRLVL PMDDSEPPLNLLDNTRHGPA |
| Tissue Specificity | Ubiquitous. High expression in brain, skeletal muscle, and heart, but is also detected at lower levels in most other tissues. |
| Post Translational Modifications | Ubiquitinated (in vitro). Glycosylated. |
| Function | Endosomal Na(+), K(+)/H(+) antiporter. Mediates the electroneutral exchange of endosomal luminal H(+) for a cytosolic Na(+) or K(+). By facilitating proton efflux, SLC9A6 counteracts the acidity generated by vacuolar (V)-ATPase, thereby limiting luminal acidification. Responsible for alkalizing and maintaining the endosomal pH, and consequently in, e.g., endosome maturation and trafficking of recycling endosomal cargo. Plays a critical role during neurodevelopment by regulating synaptic development and plasticity. Implicated in the maintenance of cell polarity in a manner that is dependent on its ability to modulate intravesicular pH. Regulates intracelular pH in some specialized cells, osteoclasts and stereocilia where this transporter localizes to the plasma membrane. |
| Protein Name | Sodium/Hydrogen Exchanger 6Na(+/H(+ Exchanger 6Nhe-6Solute Carrier Family 9 Member 6 |
| Database Links | Reactome: R-HSA-425986Reactome: R-HSA-5619092 |
| Cellular Localisation | Endosome MembraneMulti-Pass Membrane ProteinRecycling Endosome MembraneEarly Endosome MembraneLate Endosome MembraneCell MembranePresent Predominantly In The Recycling Compartments Including Early And Recycling EndosomesBut Undergoes Plasma Membrane Localization During Vesicular RecyclingWhich Is Enhanced Upon Certain StimuliSuch As HypoxiaHas A Major Plasmalemmal Distribution In A Few Specialized CellsSuch As In Vestibular Hair Bundles And Osteoblasts |
| Alternative Antibody Names | Anti-Sodium/Hydrogen Exchanger 6 antibodyAnti-Na(+/H(+ Exchanger 6 antibodyAnti-Nhe-6 antibodyAnti-Solute Carrier Family 9 Member 6 antibodyAnti-SLC9A6 antibodyAnti-KIAA0267 antibodyAnti-NHE6 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
