Anti-SLC1A3 antibody (453-542) (STJ118168)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal SLC1A3 (453-542) antibody for use in WB, IHC-P and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-P/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000IHC-P:1:100-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | SLC1A3 |
| Gene ID | 6507 |
| Uniprot ID | EAA1_HUMAN |
| Immunogen Region | 453-542 |
| Immunogen Sequence | IVLTSVGLPTDDITLIIAVD WFLDRLRTTTNVLGDSLGAG IVEHLSRHELKNRDVEMGNS VIEENEMKKPYQLIAQDNET EKPIDSETKM |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 453-542 of human EAAT1/EAAT1/SLC1A3 (NP_004163.3). |
Additional Info
| Tissue Specificity | Detected in brain. Detected at very much lower levels in heart, lung, placenta and skeletal muscle. Highly expressed in cerebellum, but also found in frontal cortex, hippocampus and basal ganglia. |
| Post Translational Modifications | Glycosylated. |
| Function | Sodium-dependent, high-affinity amino acid transporter that mediates the uptake of L-glutamate and also L-aspartate and D-aspartate. Functions as a symporter that transports one amino acid molecule together with two or three Na(+) ions and one proton, in parallel with the counter-transport of one K(+) ion. Mediates Cl(-) flux that is not coupled to amino acid transport.this avoids the accumulation of negative charges due to aspartate and Na(+) symport. Plays a redundant role in the rapid removal of released glutamate from the synaptic cleft, which is essential for terminating the postsynaptic action of glutamate. |
| Protein Name | Excitatory Amino Acid Transporter 1Sodium-Dependent Glutamate/Aspartate Transporter 1Glast-1Solute Carrier Family 1 Member 3 |
| Database Links | Reactome: R-HSA-210455Reactome: R-HSA-210500Reactome: R-HSA-425393Reactome: R-HSA-5619062 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Excitatory Amino Acid Transporter 1 antibodyAnti-Sodium-Dependent Glutamate/Aspartate Transporter 1 antibodyAnti-Glast-1 antibodyAnti-Solute Carrier Family 1 Member 3 antibodyAnti-SLC1A3 antibodyAnti-EAAT1 antibodyAnti-GLAST antibodyAnti-GLAST1 antibody |
Information sourced from Uniprot.org