Anti-RASGRP2 antibody (492-542) (STJA0006437)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from human GRP2 AA range: 492-542
General Information
| Short Description | Rabbit polyclonal anti-RAS guanyl-releasing protein 2 (492-542) for use in WB in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:1000-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | RASGRP2 |
| Gene ID | 10235 |
| Uniprot ID | GRP2_HUMAN |
| Immunogen | Synthesized peptide derived from human GRP2 AA range: 492-542 |
| Immunogen Region | 492-542 |
| Specificity | This antibody detects endogenous levels of human GRP2 |
Additional Info
| Post Translational Modifications | Isoform 2 is palmitoylated and myristoylated. |
| Function | Functions as a calcium- and DAG-regulated nucleotide exchange factor specifically activating Rap through the exchange of bound GDP for GTP. May also activate other GTPases such as RRAS, RRAS2, NRAS, KRAS but not HRAS. Functions in aggregation of platelets and adhesion of T-lymphocytes and neutrophils probably through inside-out integrin activation. May function in the muscarinic acetylcholine receptor M1/CHRM1 signaling pathway. |
| Protein Name | Ras Guanyl-Releasing Protein 2Calcium And Dag-Regulated Guanine Nucleotide Exchange Factor ICaldag-GefiCdc25-Like ProteinHcdc25lF25b3.3 Kinase-Like Protein |
| Database Links | Reactome: R-HSA-114508Reactome: R-HSA-2871837Reactome: R-HSA-354192Reactome: R-HSA-392517 |
| Cellular Localisation | CytoplasmCytosolCell MembranePeripheral Membrane ProteinSynapseSynaptosomeCell ProjectionRuffle MembraneFound Both In The Cytosol And Associated With MembranesIsoform 2 Mainly Localizes To The Cell MembraneEnriched At Juxtamembrane Areas And Membrane Ruffles Through Association With F-ActinLocalizes To The Cell Bodies And Axons Of Striatal Neurons |
| Alternative Antibody Names | Anti-Ras Guanyl-Releasing Protein 2 antibodyAnti-Calcium And Dag-Regulated Guanine Nucleotide Exchange Factor I antibodyAnti-Caldag-Gefi antibodyAnti-Cdc25-Like Protein antibodyAnti-Hcdc25l antibodyAnti-F25b3.3 Kinase-Like Protein antibodyAnti-RASGRP2 antibodyAnti-CDC25L antibodyAnti-MCG7 antibody |
Information sourced from Uniprot.org