Anti-SLC6A2 antibody (30-235) (STJ29850)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal SLC6A2 (30-235) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:1000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.05% Proclin300, 50% Glycerol, pH7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | SLC6A2 |
| Gene ID | 6530 |
| Uniprot ID | SC6A2_HUMAN |
| Immunogen Region | 30-235 |
| Immunogen Sequence | ELIPDAPLSSAAYSIRSIGE RPVLKAPVPKRQKCDHWTPC PSDTYAYRLLSGGGRSKYAK ICFEDNLLMGEQLGNVARGI NIAIVNYVTGNVTATRCFDM YEGDNSGPMTKFIQSAAPKS LLFMVTYDDGSTRLNNDAKN AIEALGSKEIRNMKFRSSWV FIAAKGLELPSEIQREKINH SDAKNNRYSGWPAEIQIEGC IPKERS |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 30-235 of human SLC6A2 (NP_478066.3). |
Additional Info
| Post Translational Modifications | Palmitoylated.palmitoylation regulates protein levels and neurotransmitter transport. |
| Function | Mediates sodium- and chloride-dependent transport of norepinephrine (also known as noradrenaline), the primary signaling neurotransmitter in the autonomic sympathetic nervous system. Is responsible for norepinephrine re-uptake and clearance from the synaptic cleft, thus playing a crucial role in norepinephrine inactivation and homeostasis. Can also mediate sodium- and chloride-dependent transport of dopamine. |
| Protein Name | Sodium-Dependent Noradrenaline TransporterNorepinephrine TransporterNetSolute Carrier Family 6 Member 2 |
| Database Links | Reactome: R-HSA-442660Reactome: R-HSA-5619109 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinCell ProjectionAxonSynapseSynaptosome |
| Alternative Antibody Names | Anti-Sodium-Dependent Noradrenaline Transporter antibodyAnti-Norepinephrine Transporter antibodyAnti-Net antibodyAnti-Solute Carrier Family 6 Member 2 antibodyAnti-SLC6A2 antibodyAnti-NAT1 antibodyAnti-NET1 antibodyAnti-SLC6A5 antibody |
Information sourced from Uniprot.org