Anti-SLC6A2 antibody (1-70) [S4951RM] (STJ11104951)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit monoclonal Sodium-Dependent Noradrenaline Transporter (1-70) antibody for use in WB and ELISA in human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | S4951RM |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:2000-1:10000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.05% Proclin300, 0.05% BSA, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | SLC6A2 |
| Gene ID | 6530 |
| Uniprot ID | SC6A2_HUMAN |
| Immunogen Region | 1-70 |
| Immunogen Sequence | MLLARMNPQVQPENNGADTG PEQPLRARKTAELLVVKERN GVQCLLAPRDGDAQPRETWG KKIDFLLSVV |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1-70 of human SLC6A2 (NP_001034.1). |
Additional Info
| Post Translational Modifications | Palmitoylated.palmitoylation regulates protein levels and neurotransmitter transport. |
| Function | Mediates sodium- and chloride-dependent transport of norepinephrine (also known as noradrenaline), the primary signaling neurotransmitter in the autonomic sympathetic nervous system. Is responsible for norepinephrine re-uptake and clearance from the synaptic cleft, thus playing a crucial role in norepinephrine inactivation and homeostasis. Can also mediate sodium- and chloride-dependent transport of dopamine. |
| Protein Name | Sodium-Dependent Noradrenaline TransporterNorepinephrine TransporterNetSolute Carrier Family 6 Member 2 |
| Database Links | Reactome: R-HSA-442660Reactome: R-HSA-5619109 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinCell ProjectionAxonSynapseSynaptosome |
| Alternative Antibody Names | Anti-Sodium-Dependent Noradrenaline Transporter antibodyAnti-Norepinephrine Transporter antibodyAnti-Net antibodyAnti-Solute Carrier Family 6 Member 2 antibodyAnti-SLC6A2 antibodyAnti-NAT1 antibodyAnti-NET1 antibodyAnti-SLC6A5 antibody |
Information sourced from Uniprot.org