Anti-SLC47A2 antibody (Internal) (STJ72481)
SPECIFICATIONS
ClonalityPolyclonal
HostGoat
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Goat polyclonal antibody anti-SLC47A2 (Internal) is suitable for use in ELISA and Western Blot research applications. |
| Applications | Pep-ELISA/WB |
| Host | Goat |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.5 mg/mL |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Dilution Range | Peptide ELISA: antibody detection limit dilution 1:32000.WB: Approx 60kDa band observed in Human Testis lysates (calculated MW of 61.0kDa according to NP_001093116.1). Recommended concentration: 0.1-0.3µg/ml. |
| Formulation | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Storage Instruction | Store at-20°C on receipt and minimise freeze-thaw cycles. |
Target Information
| Gene Symbol | SLC47A2 |
| Gene ID | 146802 |
| Uniprot ID | S47A2_HUMAN |
| Accession Number | NP_690872.2; NP_001093116.1 |
| Immunogen Region | Internal |
| Immunogen Sequence | QRAESTATRPGPEK |
| Specificity | This antibody is expected to recognize both reported isoforms (NP_690872.2; NP_001093116.1). |
Additional Info
| Function | Multidrug efflux pump that functions as a H(+)/organic cation antiporter. Mediates the efflux of cationic compounds, such as the model cations, tetraethylammonium (TEA) and 1-methyl-4-phenylpyridinium (MPP+), the platinum-based drug oxaliplatin or weak bases that are positively charged at physiological pH, cimetidine, the platinum-based drugs cisplatin and oxaliplatin or the antidiabetic drug metformin. Mediates the efflux of endogenous compounds such as, creatinine, thiamine and estrone-3-sulfate. Plays a physiological role in the excretion of drugs, toxins and endogenous metabolites through the kidney. Isoform 6: Non-functional protein. |
| Protein Name | Multidrug And Toxin Extrusion Protein 2Mate-2Hmate-2Kidney-Specific H(+/Organic Cation AntiporterSolute Carrier Family 47 Member 2 |
| Database Links | Reactome: R-HSA-425366 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinApical Cell MembraneDetected In The Renal Urinary TubulesIsoform 6: Apical Cell MembraneLocalized At The Brush Border Membranes Of The Proximal Tubules |
| Alternative Antibody Names | Anti-Multidrug And Toxin Extrusion Protein 2 antibodyAnti-Mate-2 antibodyAnti-Hmate-2 antibodyAnti-Kidney-Specific H(+/Organic Cation Antiporter antibodyAnti-Solute Carrier Family 47 Member 2 antibodyAnti-SLC47A2 antibodyAnti-MATE2 antibody |
Information sourced from Uniprot.org