| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Amino acid transporter heavy chain SLC3A1-type amino acid transporter-related heavy chain is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
SLC3A1 |
| Gene ID: |
6519 |
| Uniprot ID: |
SLC31_HUMAN |
| Specificity: |
This antibody detects endogenous levels of SLC3A1 at Human, Rat |
| Immunogen: |
Synthesized peptide derived from human SLC3A1 |
| Function | Acts as a chaperone that facilitates biogenesis and trafficking of functional transporter heteromers to the plasma membrane. Associates with SLC7A9 to form a functional transporter complex that mediates the electrogenic exchange between cationic amino acids and neutral amino acids, with a stoichiometry of 1:1. SLC7A9-SLC3A1 transporter has system b(0,+)-like activity with high affinity for extracellular cationic amino acids and L-cystine and lower affinity for intracellular neutral amino acids. Substrate exchange is driven by high concentration of intracellular neutral amino acids and the intracellular reduction of L-cystine to L-cysteine. SLC7A9-SLC3A1 acts as a major transporter for reabsorption of L-cystine and dibasic amino acids across the brush border membrane in early proximal tubules. Associates with SLC7A13 to form a functional complex that transports anionic and neutral amino acids via exchange or facilitated diffusion. SLC7A13-SLC3A1 may act as a major transporter for L-cystine in late proximal tubules, ensuring its reabsorption from the luminal fluid in exchange for cytosolic L-glutamate or L-aspartate. |
| Protein Name | Amino Acid Transporter Heavy Chain Slc3a1D2hNeutral And Basic Amino Acid Transport ProteinNbatSolute Carrier Family 3 Member 1B(0 -+-Type Amino Acid Transporter-Related Heavy ChainRbat |
| Database Links | Reactome: R-HSA-352230Reactome: R-HSA-5619113Reactome: R-HSA-5660883 |
| Cellular Localisation | Cell MembraneSingle-Pass Type Ii Membrane ProteinApical Cell Membrane |
| Alternative Antibody Names | Anti-Amino Acid Transporter Heavy Chain Slc3a1 antibodyAnti-D2h antibodyAnti-Neutral And Basic Amino Acid Transport Protein antibodyAnti-Nbat antibodyAnti-Solute Carrier Family 3 Member 1 antibodyAnti-B(0 -+-Type Amino Acid Transporter-Related Heavy Chain antibodyAnti-Rbat antibodyAnti-SLC3A1 antibodyAnti-NBAT antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
