Anti-SLC3A1 antibody (STJA0007052)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from human SLC3A1
General Information
| Short Description | Rabbit polyclonal anti-Amino acid transporter heavy chain SLC3A1-type amino acid transporter-related heavy chain for use in WB in Human and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | SLC3A1 |
| Gene ID | 6519 |
| Uniprot ID | SLC31_HUMAN |
| Immunogen | Synthesized peptide derived from human SLC3A1 |
| Specificity | This antibody detects endogenous levels of SLC3A1 at Human, Rat |
Additional Info
| Function | Acts as a chaperone that facilitates biogenesis and trafficking of functional transporter heteromers to the plasma membrane. Associates with SLC7A9 to form a functional transporter complex that mediates the electrogenic exchange between cationic amino acids and neutral amino acids, with a stoichiometry of 1:1. SLC7A9-SLC3A1 transporter has system b(0,+)-like activity with high affinity for extracellular cationic amino acids and L-cystine and lower affinity for intracellular neutral amino acids. Substrate exchange is driven by high concentration of intracellular neutral amino acids and the intracellular reduction of L-cystine to L-cysteine. SLC7A9-SLC3A1 acts as a major transporter for reabsorption of L-cystine and dibasic amino acids across the brush border membrane in early proximal tubules. Associates with SLC7A13 to form a functional complex that transports anionic and neutral amino acids via exchange or facilitated diffusion. SLC7A13-SLC3A1 may act as a major transporter for L-cystine in late proximal tubules, ensuring its reabsorption from the luminal fluid in exchange for cytosolic L-glutamate or L-aspartate. |
| Protein Name | Amino Acid Transporter Heavy Chain Slc3a1D2hNeutral And Basic Amino Acid Transport ProteinNbatSolute Carrier Family 3 Member 1B(0 -+-Type Amino Acid Transporter-Related Heavy ChainRbat |
| Database Links | Reactome: R-HSA-352230Reactome: R-HSA-5619113Reactome: R-HSA-5660883 |
| Cellular Localisation | Cell MembraneSingle-Pass Type Ii Membrane ProteinApical Cell Membrane |
| Alternative Antibody Names | Anti-Amino Acid Transporter Heavy Chain Slc3a1 antibodyAnti-D2h antibodyAnti-Neutral And Basic Amino Acid Transport Protein antibodyAnti-Nbat antibodyAnti-Solute Carrier Family 3 Member 1 antibodyAnti-B(0 -+-Type Amino Acid Transporter-Related Heavy Chain antibodyAnti-Rbat antibodyAnti-SLC3A1 antibodyAnti-NBAT antibody |
Information sourced from Uniprot.org