| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human/Rat/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Zinc transporter ZIP4 (431-480 aa) is suitable for use in Western Blot and ELISA research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-1:2000ELISA 1:40000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
SLC39A4 |
| Gene ID: |
55630 |
| Uniprot ID: |
S39A4_HUMAN |
| Immunogen Region: |
431-480 aa |
| Specificity: |
ZIP4 Polyclonal Antibody detects endogenous levels of ZIP4 protein. |
| Immunogen: |
The antiserum was produced against synthesized peptide derived from the human SLC39A4 at the amino acid range 431-480 |
| Post Translational Modifications | The extracellular N-terminal ectodomain is cleaved when cells are Zn(2+) deficient, N-terminally cleaved SLC39A4 is internalized at a faster rate. Under excess Zn(2+) conditions, SLC39A4 on the cell surface is rapidly endocytosed, ubiquitinated and degraded. Glycosylated. |
| Function | Selective transporter that mediates the uptake of Zn(2+). Plays an essential role for dietary zinc uptake from small intestine. The Zn(2+) uniporter activity is regulated by zinc availability. Exhibits also polyspecific binding and transport of Cu(2+), Cd(2+) and possibly Ni(2+) but at higher concentrations. |
| Protein Name | Zinc Transporter Zip4Solute Carrier Family 39 Member 4Zrt- And Irt-Like Protein 4Zip-4 |
| Database Links | Reactome: R-HSA-442380Reactome: R-HSA-5619088 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinRecycling Endosome MembraneApical Cell MembraneColocalized With Tfrc In The Recycling EndosomesCycles Between Endosomal Compartments And The Plasma Membrane In Response To Zn(2+) AvailabilityZn(2+) Deficiency Promotes Accumulation Of Slc39a4 On The Surface MembraneWhereas High Extracellular Zn(2+) Levels Induce Internalization Of Slc39a4But Also Trigger Drastic Removal Of Cellular Slc39a4 Via Proteasomal And Lysosomal Degradation Pathways |
| Alternative Antibody Names | Anti-Zinc Transporter Zip4 antibodyAnti-Solute Carrier Family 39 Member 4 antibodyAnti-Zrt- And Irt-Like Protein 4 antibodyAnti-Zip-4 antibodyAnti-SLC39A4 antibodyAnti-ZIP4 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
