Anti-SLC39A4 antibody (431-480 aa) (STJ96314)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThe antiserum was produced against synthesized peptide derived from the human SLC39A4 at the amino acid range 431-480
General Information
| Short Description | Rabbit polyclonal anti-Zinc transporter ZIP4 (431-480 aa) for use in WB and ELISA in Human, Rat and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Rat/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-1:2000ELISA 1:40000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | SLC39A4 |
| Gene ID | 55630 |
| Uniprot ID | S39A4_HUMAN |
| Immunogen | The antiserum was produced against synthesized peptide derived from the human SLC39A4 at the amino acid range 431-480 |
| Immunogen Region | 431-480 aa |
| Specificity | ZIP4 Polyclonal Antibody detects endogenous levels of ZIP4 protein. |
Additional Info
| Post Translational Modifications | The extracellular N-terminal ectodomain is cleaved when cells are Zn(2+) deficient, N-terminally cleaved SLC39A4 is internalized at a faster rate. Under excess Zn(2+) conditions, SLC39A4 on the cell surface is rapidly endocytosed, ubiquitinated and degraded. Glycosylated. |
| Function | Selective transporter that mediates the uptake of Zn(2+). Plays an essential role for dietary zinc uptake from small intestine. The Zn(2+) uniporter activity is regulated by zinc availability. Also exhibits polyspecific binding and transport of Cu(2+), Cd(2+) and possibly Ni(2+) but at higher concentrations. |
| Protein Name | Zinc Transporter Zip4Solute Carrier Family 39 Member 4Zrt- And Irt-Like Protein 4Zip-4 |
| Database Links | Reactome: R-HSA-442380Reactome: R-HSA-5619088 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinRecycling Endosome MembraneApical Cell MembraneColocalized With Tfrc In The Recycling EndosomesCycles Between Endosomal Compartments And The Plasma Membrane In Response To Zn(2+) AvailabilityZn(2+) Deficiency Promotes Accumulation Of Slc39a4 On The Surface MembraneWhereas High Extracellular Zn(2+) Levels Induce Internalization Of Slc39a4But Also Trigger Drastic Removal Of Cellular Slc39a4 Via Proteasomal And Lysosomal Degradation Pathways |
| Alternative Antibody Names | Anti-Zinc Transporter Zip4 antibodyAnti-Solute Carrier Family 39 Member 4 antibodyAnti-Zrt- And Irt-Like Protein 4 antibodyAnti-Zip-4 antibodyAnti-SLC39A4 antibodyAnti-ZIP4 antibody |
Information sourced from Uniprot.org