| Tissue Specificity | Isoform 1: Expressed in liver, kidney, placenta, intestine, brain, heart, and colon. Predominantly expressed in liver. Isoform 2: Expressed in liver, placenta, and intestine, but much lower relative to isoform 1. |
| Function | Mediates the import of long-chain fatty acids (LCFA) into the cell by facilitating their transport across cell membranes, playing an important role in hepatic fatty acid uptake. Also functions as an acyl-CoA ligase catalyzing the ATP-dependent formation of fatty acyl-CoA using LCFA and very-long-chain fatty acids (VLCFA) as substrates, which prevents fatty acid efflux from cells and might drive more fatty acid uptake. Plays a pivotal role in regulating available LCFA substrates from exogenous sources in tissues undergoing high levels of beta-oxidation or triglyceride synthesis. Can also activate branched-chain fatty acids such as phytanic acid and pristanic acid. May contribute to the synthesis of sphingosine-1-phosphate. Does not activate C24 bile acids, cholate and chenodeoxycholate. In vitro, activates 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanate (THCA), the C27 precursor of cholic acid deriving from the de novo synthesis from cholesterol. However, it is not critical for THCA activation and bile synthesis in vivo. Isoform 1: Exhibits both long-chain fatty acids (LCFA) transport activity and acyl CoA synthetase towards very long-chain fatty acids. Shows a preference for generating CoA derivatives of n-3 fatty acids, which are preferentially trafficked into phosphatidylinositol. Isoform 2: Exhibits long-chain fatty acids (LCFA) transport activity but lacks acyl CoA synthetase towards very long-chain fatty acids. |
| Protein Name | Long-Chain Fatty Acid Transport Protein 2Arachidonate--Coa LigaseFatty Acid Transport Protein 2Fatp-2Fatty-Acid-Coenzyme A Ligase - Very Long-Chain 1Long-Chain-Fatty-Acid--Coa LigasePhytanate--Coa LigaseSolute Carrier Family 27 Member 2Thca-Coa LigaseVery Long-Chain Acyl-Coa SynthetaseVlacsVlcsVery Long-Chain-Fatty-Acid-Coa Ligase |
| Database Links | Reactome: R-HSA-193368Reactome: R-HSA-193775Reactome: R-HSA-389599Reactome: R-HSA-6798695Reactome: R-HSA-75105Reactome: R-HSA-9033241 |
| Cellular Localisation | Endoplasmic Reticulum MembraneMulti-Pass Membrane ProteinPeroxisome MembranePeripheral Membrane ProteinCell MembraneMicrosome |
| Alternative Antibody Names | Anti-Long-Chain Fatty Acid Transport Protein 2 antibodyAnti-Arachidonate--Coa Ligase antibodyAnti-Fatty Acid Transport Protein 2 antibodyAnti-Fatp-2 antibodyAnti-Fatty-Acid-Coenzyme A Ligase - Very Long-Chain 1 antibodyAnti-Long-Chain-Fatty-Acid--Coa Ligase antibodyAnti-Phytanate--Coa Ligase antibodyAnti-Solute Carrier Family 27 Member 2 antibodyAnti-Thca-Coa Ligase antibodyAnti-Very Long-Chain Acyl-Coa Synthetase antibodyAnti-Vlacs antibodyAnti-Vlcs antibodyAnti-Very Long-Chain-Fatty-Acid-Coa Ligase antibodyAnti-SLC27A2 antibodyAnti-ACSVL1 antibodyAnti-FACVL1 antibodyAnti-FATP2 antibodyAnti-VLACS antibody |
Information sourced from Uniprot.org
