Anti-SLC27A1 antibody (510-646) (STJ114713)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal SLC27A1 (510-646) antibody for use in WB, IF, ICC and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IF/ICC/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:1000-1:2000IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.09% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | SLC27A1 |
| Gene ID | 376497 |
| Uniprot ID | S27A1_HUMAN |
| Immunogen Region | 510-646 |
| Immunogen Sequence | DTFRWRGENVSTTEVEGVLS RLLGQTDVAVYGVAVPGVEG KAGMAAVADPHSLLDPNAIY QELQKVLAPYARPIFLRLLP QVDTTGTFKIQKTRLQREGF DPRQTSDRLFFLDLKQGHYL PLNEAVYTRICSGAFAL |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 510-646 of human SLC27A1 (NP_940982.1). |
Additional Info
| Tissue Specificity | Highest levels of expression are detected in muscle and adipose tissue small, intermediate levels in small intestine, and barely detectable in liver. Expressed in brain gray matter. |
| Function | Mediates the import of long-chain fatty acids (LCFA) into the cell by facilitating their transport at the plasma membrane. Also functions as an acyl-CoA ligase catalyzing the ATP-dependent formation of fatty acyl-CoA using LCFA and very-long-chain fatty acids (VLCFA) as substrates, which prevents fatty acid efflux from cells and might drive more fatty acid uptake. May act directly as a bona fide transporter, or alternatively, in a cytoplasmic or membrane-associated multimeric protein complex to trap and draw fatty acids towards accumulation. Plays a pivotal role in regulating available LCFA substrates from exogenous sources in tissues undergoing high levels of beta-oxidation or triglyceride synthesis. May be involved in regulation of cholesterol metabolism. Probably involved in fatty acid transport across the blood barrier. |
| Protein Name | Long-Chain Fatty Acid Transport Protein 1Arachidonate--Coa LigaseFatty Acid Transport Protein 1Fatp-1Long-Chain-Fatty-Acid--Coa LigaseSolute Carrier Family 27 Member 1Very Long-Chain Acyl-Coa Synthetase |
| Database Links | Reactome: R-HSA-1989781Reactome: R-HSA-2142753Reactome: R-HSA-804914 |
| Cellular Localisation | Cell MembraneSingle-Pass Membrane ProteinEndomembrane SystemCytoplasmPlasma Membrane And Intracellular MembranesAt Least In AdipocytesIn AdipocytesBut Not MyocytesInsulin Via The Mtorc1 Signaling Pathway Induces A Rapid Translocation Of Slc27a1 From Intracellular Compartments To The Plasma MembraneParalleled By Increased Lcfa UptakeInsulin-Dependent Translocation From The Cytoplasm To The Cell Membrane Is Regulated By Eprs1Predominantly Cytoplasmic In Myocytes |
| Alternative Antibody Names | Anti-Long-Chain Fatty Acid Transport Protein 1 antibodyAnti-Arachidonate--Coa Ligase antibodyAnti-Fatty Acid Transport Protein 1 antibodyAnti-Fatp-1 antibodyAnti-Long-Chain-Fatty-Acid--Coa Ligase antibodyAnti-Solute Carrier Family 27 Member 1 antibodyAnti-Very Long-Chain Acyl-Coa Synthetase antibodyAnti-SLC27A1 antibodyAnti-ACSVL5 antibodyAnti-FATP1 antibody |
Information sourced from Uniprot.org