| Host: |
Rabbit |
| Applications: |
WB/IF |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-SLC27A1 (510-646) is suitable for use in Western Blot and Immunofluorescence research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:1000-1:2000IF/ICC 1:50-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
SLC27A1 |
| Gene ID: |
376497 |
| Uniprot ID: |
S27A1_HUMAN |
| Immunogen Region: |
510-646 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 510-646 of human SLC27A1 (NP_940982.1). |
| Immunogen Sequence: |
DTFRWRGENVSTTEVEGVLS RLLGQTDVAVYGVAVPGVEG KAGMAAVADPHSLLDPNAIY QELQKVLAPYARPIFLRLLP QVDTTGTFKIQKTRLQREGF DPRQTSDRLFFLDLKQGHYL PLNEAVYTRICSGAFAL |
| Tissue Specificity | Highest levels of expression are detected in muscle and adipose tissue small, intermediate levels in small intestine, and barely detectable in liver. Expressed in brain gray matter. |
| Function | Mediates the import of long-chain fatty acids (LCFA) into the cell by facilitating their transport at the plasma membrane. Also functions as an acyl-CoA ligase catalyzing the ATP-dependent formation of fatty acyl-CoA using LCFA and very-long-chain fatty acids (VLCFA) as substrates, which prevents fatty acid efflux from cells and might drive more fatty acid uptake. May act directly as a bona fide transporter, or alternatively, in a cytoplasmic or membrane-associated multimeric protein complex to trap and draw fatty acids towards accumulation. Plays a pivotal role in regulating available LCFA substrates from exogenous sources in tissues undergoing high levels of beta-oxidation or triglyceride synthesis. May be involved in regulation of cholesterol metabolism. Probably involved in fatty acid transport across the blood barrier. |
| Protein Name | Long-Chain Fatty Acid Transport Protein 1Arachidonate--Coa LigaseFatty Acid Transport Protein 1Fatp-1Long-Chain-Fatty-Acid--Coa LigaseSolute Carrier Family 27 Member 1Very Long-Chain Acyl-Coa Synthetase |
| Database Links | Reactome: R-HSA-1989781Reactome: R-HSA-804914 |
| Cellular Localisation | Cell MembraneSingle-Pass Membrane ProteinEndomembrane SystemCytoplasmPlasma Membrane And Intracellular MembranesAt Least In AdipocytesIn AdipocytesBut Not MyocytesInsulin Via The Mtorc1 Signaling Pathway Induces A Rapid Translocation Of Slc27a1 From Intracellular Compartments To The Plasma MembraneParalleled By Increased Lcfa UptakeInsulin-Dependent Translocation From The Cytoplasm To The Cell Membrane Is Regulated By Eprs1Predominantly Cytoplasmic In Myocytes |
| Alternative Antibody Names | Anti-Long-Chain Fatty Acid Transport Protein 1 antibodyAnti-Arachidonate--Coa Ligase antibodyAnti-Fatty Acid Transport Protein 1 antibodyAnti-Fatp-1 antibodyAnti-Long-Chain-Fatty-Acid--Coa Ligase antibodyAnti-Solute Carrier Family 27 Member 1 antibodyAnti-Very Long-Chain Acyl-Coa Synthetase antibodyAnti-SLC27A1 antibodyAnti-ACSVL5 antibodyAnti-FATP1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
