| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-SLC26A3 (505-764) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
SLC26A3 |
| Gene ID: |
1811 |
| Uniprot ID: |
S26A3_HUMAN |
| Immunogen Region: |
505-764 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 505-764 of human SLC26A3 (NP_000102.1). |
| Immunogen Sequence: |
FPKCSTLANIGRTNIYKNKK DYYDMYEPEGVKIFRCPSPI YFANIGFFRRKLIDAVGFSP LRILRKRNKALRKIRKLQKQ GLLQVTPKGFICTVDTIKDS DEELDNNQIEVLDQPINTTD LPFHIDWNDDLPLNIEVPKI SLHSLILDFSAVSFLDVSSV RGLKSILQEFIRIKVDVYIV GTDDDFIEKLNRYEFFDGEV KSSIFFLTIHDAVLHILMKK DYSTSKFNPSQEKDGKIDF |
| Tissue Specificity | Expressed in the colon. Expression is significantly decreased in adenomas (polyps) and adenocarcinomas of the colon. |
| Post Translational Modifications | N-glycosylation is required for efficient cell surface expression, and protection from proteolytic degradation. |
| Function | Mediates chloride-bicarbonate exchange with a chloride bicarbonate stoichiometry of 2:1 in the intestinal epithelia. Plays a role in the chloride and bicarbonate homeostasis during sperm epididymal maturation and capacitation. |
| Protein Name | Chloride Anion ExchangerDown-Regulated In AdenomaProtein DraSolute Carrier Family 26 Member 3 |
| Database Links | Reactome: R-HSA-427601Reactome: R-HSA-5619085 |
| Cellular Localisation | Apical Cell MembraneMulti-Pass Membrane ProteinMembraneCell MembraneLocalized In Sperm MembranesMidpiece Of Sperm TailColocalizes With Cftr At The Midpiece Of Sperm Tail |
| Alternative Antibody Names | Anti-Chloride Anion Exchanger antibodyAnti-Down-Regulated In Adenoma antibodyAnti-Protein Dra antibodyAnti-Solute Carrier Family 26 Member 3 antibodyAnti-SLC26A3 antibodyAnti-DRA antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
