Anti-SLC26A3 antibody (505-764) (STJ28824)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal SLC26A3 (505-764) antibody for use in WB and ELISA in human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | SLC26A3 |
| Gene ID | 1811 |
| Uniprot ID | S26A3_HUMAN |
| Immunogen Region | 505-764 |
| Immunogen Sequence | FPKCSTLANIGRTNIYKNKK DYYDMYEPEGVKIFRCPSPI YFANIGFFRRKLIDAVGFSP LRILRKRNKALRKIRKLQKQ GLLQVTPKGFICTVDTIKDS DEELDNNQIEVLDQPINTTD LPFHIDWNDDLPLNIEVPKI SLHSLILDFSAVSFLDVSSV RGLKSILQEFIRIKVDVYIV GTDDDFIEKLNRYEFFDGEV KSSIFFLTIHDAVLHILMKK DYSTSKFNPSQEKDGKIDF |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 505-764 of human SLC26A3 (NP_000102.1). |
Additional Info
| Tissue Specificity | Expressed in the colon. Expression is significantly decreased in adenomas (polyps) and adenocarcinomas of the colon. |
| Post Translational Modifications | N-glycosylation is required for efficient cell surface expression, and protection from proteolytic degradation. |
| Function | Mediates chloride-bicarbonate exchange with a chloride bicarbonate stoichiometry of 2:1 in the intestinal epithelia. Plays a role in the chloride and bicarbonate homeostasis during sperm epididymal maturation and capacitation. |
| Protein Name | Chloride Anion ExchangerDown-Regulated In AdenomaProtein DraSolute Carrier Family 26 Member 3 |
| Database Links | Reactome: R-HSA-427601Reactome: R-HSA-5619085 |
| Cellular Localisation | Apical Cell MembraneMulti-Pass Membrane ProteinMembraneCell MembraneLocalized In Sperm MembranesMidpiece Of Sperm TailColocalizes With Cftr At The Midpiece Of Sperm Tail |
| Alternative Antibody Names | Anti-Chloride Anion Exchanger antibodyAnti-Down-Regulated In Adenoma antibodyAnti-Protein Dra antibodyAnti-Solute Carrier Family 26 Member 3 antibodyAnti-SLC26A3 antibodyAnti-DRA antibody |
Information sourced from Uniprot.org