Anti-SLC22A7 antibody (50-142) (STJ117331)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal SLC22A7 (50-142) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | SLC22A7 |
| Gene ID | 10864 |
| Uniprot ID | S22A7_HUMAN |
| Immunogen Region | 50-142 |
| Immunogen Sequence | ALPGAPANFSHQDVWLEAHL PREPDGTLSSCLRFAYPQAL PNTTLGEERQSRGELEDEPA TVPCSQGWEYDHSEFSSTIA TESQWDLVCEQKG |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 50-142 of human SLC22A7 (NP_696961.2). |
Additional Info
| Tissue Specificity | Mainly expressed in liver and kidney. In kidney, expressed in proximal tubular cells. Also expressed in pancreas, small intestine, spinal cord, lung, brain and heart. Expressed in fetal liver. |
| Function | Isoform 2: Functions as a Na(+)-independent bidirectional multispecific transporter. Contributes to the renal and hepatic elimination of endogenous organic compounds from the systemic circulation into the urine and bile, respectively. Capable of transporting a wide range of purine and pyrimidine nucleobases, nucleosides and nucleotides, with cGMP, 2'deoxyguanosine and GMP being the preferred substrates. Functions as a pH- and chloride-independent cGMP bidirectional facilitative transporter that can regulate both intracellular and extracellular levels of cGMP and may be involved in cGMP signaling pathways. Mediates orotate/glutamate bidirectional exchange and most likely display a physiological role in hepatic release of glutamate into the blood. Involved in renal secretion and possible reabsorption of creatinine. Able to uptake prostaglandin E2 (PGE2) and may contribute to PGE2 renal excretion (Probable). Also transports alpha-ketoglutarate and urate. Apart from the orotate/glutamate exchange, the counterions for the uptake of other SLC22A7/OAT2 substrates remain to be identified. Isoform 1: Non functional transporter. Isoform 3: Involved in the uptake of prostaglandin F2-alpha (PGF2-alpha). |
| Protein Name | Solute Carrier Family 22 Member 7Novel Liver TransporterNltOrganic Anion Transporter 2Hoat2 |
| Database Links | Reactome: R-HSA-561048Reactome: R-HSA-9749641 |
| Cellular Localisation | Isoform 2: Basolateral Cell MembraneMulti-Pass Membrane ProteinApical Cell MembraneCell MembraneLocalized To The Basolateral Side Of The Proximal TubulesApical Side Of The Renal TubuleIsoform 1: CytoplasmCytosol |
| Alternative Antibody Names | Anti-Solute Carrier Family 22 Member 7 antibodyAnti-Novel Liver Transporter antibodyAnti-Nlt antibodyAnti-Organic Anion Transporter 2 antibodyAnti-Hoat2 antibodyAnti-SLC22A7 antibodyAnti-NLT antibodyAnti-OAT2 antibody |
Information sourced from Uniprot.org