| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-SIX5 (1-170) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
SIX5 |
| Gene ID: |
147912 |
| Uniprot ID: |
SIX5_HUMAN |
| Immunogen Region: |
1-170 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-170 of human SIX5 (NP_787071.2). |
| Immunogen Sequence: |
MATLPAEPSAGPAAGGEAVA AAAATEEEEEEARQLLQTLQ AAEGEAAAAAGAGAGAAAAG AEGPGSPGVPGSPPEAASEP PTGLRFSPEQVACVCEALLQ AGHAGRLSRFLGALPPAERL RGSDPVLRARALVAFQRGEY AELYRLLESRPFPAAHHAFL QDLYLRARYH |
| Tissue Specificity | Expressed in adult but not in fetal eyes. Found in corneal epithelium and endothelium, lens epithelium, ciliary body epithelia, cellular layers of the retina and the sclera. |
| Function | Transcription factor that is thought to be involved in regulation of organogenesis. May be involved in determination and maintenance of retina formation. Binds a 5'-GGTGTCAG-3' motif present in the ARE regulatory element of ATP1A1. Binds a 5'-TCAAGAGTTNC-3' motif present in the MEF3 element in the myogenin promoter, and in the IGFBP5 promoter. Thought to be regulated by association with Dach and Eya proteins, and seems to be coactivated by EYA1, EYA2 and EYA3. |
| Protein Name | Homeobox Protein Six5Dm Locus-Associated Homeodomain ProteinSine Oculis Homeobox Homolog 5 |
| Cellular Localisation | CytoplasmNucleus |
| Alternative Antibody Names | Anti-Homeobox Protein Six5 antibodyAnti-Dm Locus-Associated Homeodomain Protein antibodyAnti-Sine Oculis Homeobox Homolog 5 antibodyAnti-SIX5 antibodyAnti-DMAHP antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
