| Short Description : | Rabbit polyclonal SIX5 (1-170) antibody for use in WB and ELISA in mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/ELISA |
| Host: | Rabbit |
| Reactivity: | Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | Lot specific |
| Purification: | Affinity purification |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | SIX5 |
| Gene ID: | 147912 |
| Uniprot ID: | SIX5_HUMAN |
| Immunogen Region: | 1-170 |
| Immunogen Sequence: | MATLPAEPSAGPAAGGEAVA AAAATEEEEEEARQLLQTLQ AAEGEAAAAAGAGAGAAAAG AEGPGSPGVPGSPPEAASEP PTGLRFSPEQVACVCEALLQ AGHAGRLSRFLGALPPAERL RGSDPVLRARALVAFQRGEY AELYRLLESRPFPAAHHAFL QDLYLRARYH |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-170 of human SIX5 (NP_787071.2). |
| Tissue Specificity | Expressed in adult but not in fetal eyes. Found in corneal epithelium and endothelium, lens epithelium, ciliary body epithelia, cellular layers of the retina and the sclera. |
| Function | Transcription factor that is thought to be involved in regulation of organogenesis. May be involved in determination and maintenance of retina formation. Binds a 5'-GGTGTCAG-3' motif present in the ARE regulatory element of ATP1A1. Binds a 5'-TCAAGAGTTNC-3' motif present in the MEF3 element in the myogenin promoter, and in the IGFBP5 promoter. Thought to be regulated by association with Dach and Eya proteins, and seems to be coactivated by EYA1, EYA2 and EYA3. |
| Protein Name | Homeobox Protein Six5Dm Locus-Associated Homeodomain ProteinSine Oculis Homeobox Homolog 5 |
| Database Links | |
| Cellular Localisation | CytoplasmNucleus |
| Alternative Antibody Names | Anti-Homeobox Protein Six5 antibodyAnti-Dm Locus-Associated Homeodomain Protein antibodyAnti-Sine Oculis Homeobox Homolog 5 antibodyAnti-SIX5 antibodyAnti-DMAHP antibody |
Information sourced from Uniprot.org
