Anti-SIGIRR antibody (STJ192034)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from part of the human protein
General Information
| Short Description | Rabbit polyclonal anti-Single Ig IL-1-related receptor for use in WB and ELISA in Human, Rat and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Rat/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | SIGIRR |
| Gene ID | 59307 |
| Uniprot ID | SIGIR_HUMAN |
| Immunogen | Synthesized peptide derived from part of the human protein |
| Specificity | SIGIR Polyclonal Antibody detects endogenous levels of protein. |
Additional Info
| Function | Acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. Attenuates the recruitment of receptor-proximal signaling components to the TLR4 receptor, probably through an TIR-TIR domain interaction with TLR4. Through its extracellular domain interferes with the heterodimerization of Il1R1 and IL1RAP. |
| Protein Name | Single Ig Il-1-Related ReceptorSingle Ig Il-1r-Related MoleculeSingle Immunoglobulin Domain-Containing Il1r-Related ProteinToll/Interleukin-1 Receptor 8Tir8 |
| Database Links | Reactome: R-HSA-166058Reactome: R-HSA-9008059 |
| Cellular Localisation | MembraneSingle-Pass Type Iii Membrane Protein |
| Alternative Antibody Names | Anti-Single Ig Il-1-Related Receptor antibodyAnti-Single Ig Il-1r-Related Molecule antibodyAnti-Single Immunoglobulin Domain-Containing Il1r-Related Protein antibodyAnti-Toll/Interleukin-1 Receptor 8 antibodyAnti-Tir8 antibodyAnti-SIGIRR antibodyAnti-UNQ301 antibodyAnti-PRO342 antibody |
Information sourced from Uniprot.org