| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human/Rat/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Single Ig IL-1-related receptor is suitable for use in Western Blot and ELISA research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-2000ELISA 1:5000-20000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
SIGIRR |
| Gene ID: |
59307 |
| Uniprot ID: |
SIGIR_HUMAN |
| Specificity: |
SIGIR Polyclonal Antibody detects endogenous levels of protein. |
| Immunogen: |
Synthesized peptide derived from part of the human protein |
| Function | Acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. Attenuates the recruitment of receptor-proximal signaling components to the TLR4 receptor, probably through an TIR-TIR domain interaction with TLR4. Through its extracellular domain interferes with the heterodimerization of Il1R1 and IL1RAP. |
| Protein Name | Single Ig Il-1-Related ReceptorSingle Ig Il-1r-Related MoleculeSingle Immunoglobulin Domain-Containing Il1r-Related ProteinToll/Interleukin-1 Receptor 8Tir8 |
| Database Links | Reactome: R-HSA-166058Reactome: R-HSA-9008059 |
| Cellular Localisation | MembraneSingle-Pass Type Iii Membrane Protein |
| Alternative Antibody Names | Anti-Single Ig Il-1-Related Receptor antibodyAnti-Single Ig Il-1r-Related Molecule antibodyAnti-Single Immunoglobulin Domain-Containing Il1r-Related Protein antibodyAnti-Toll/Interleukin-1 Receptor 8 antibodyAnti-Tir8 antibodyAnti-SIGIRR antibodyAnti-UNQ301 antibodyAnti-PRO342 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
