| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-SERPINB6 (180-300) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:1000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
SERPINB6 |
| Gene ID: |
5269 |
| Uniprot ID: |
SPB6_HUMAN |
| Immunogen Region: |
180-300 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 180-300 of human SERPINB6 (NP_004559.4). |
| Immunogen Sequence: |
ENTEERLFKVSKNEEKPVQM MFKQSTFKKTYIGEIFTQIL VLPYVGKELNMIIMLPDETT DLRTVEKELTYEKFVEWTRL DMMDEEEVEVSLPRFKLEES YDMESVLRNLGMTDAFELGK A |
| Tissue Specificity | Expressed in keratinocytes (at protein level). Highest levels in skeletal muscle. Also found in placenta, cardiac muscle, lung, liver, kidney and pancreas. Expressed in the inner ear hair cells. Expressed abundantly by normal mast cells in different tissues and by mast cells in mastocytoma lesions. |
| Function | May be involved in the regulation of serine proteinases present in the brain or extravasated from the blood. Inhibitor of cathepsin G, kallikrein-8 and thrombin. May play an important role in the inner ear in the protection against leakage of lysosomal content during stress and loss of this protection results in cell death and sensorineural hearing loss. |
| Protein Name | Serpin B6Cytoplasmic AntiproteinaseCapPeptidase Inhibitor 6Pi-6Placental Thrombin Inhibitor |
| Database Links | Reactome: R-HSA-6798695Reactome: R-HSA-75205 |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Serpin B6 antibodyAnti-Cytoplasmic Antiproteinase antibodyAnti-Cap antibodyAnti-Peptidase Inhibitor 6 antibodyAnti-Pi-6 antibodyAnti-Placental Thrombin Inhibitor antibodyAnti-SERPINB6 antibodyAnti-PI6 antibodyAnti-PTI antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
