| Short Description : | Rabbit polyclonal SERPINB6 (180-300) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/ELISA |
| Host: | Rabbit |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | Lot specific |
| Purification: | Affinity purification |
| Dilution Range: | WB:1:500-1:1000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | SERPINB6 |
| Gene ID: | 5269 |
| Uniprot ID: | SPB6_HUMAN |
| Immunogen Region: | 180-300 |
| Immunogen Sequence: | ENTEERLFKVSKNEEKPVQM MFKQSTFKKTYIGEIFTQIL VLPYVGKELNMIIMLPDETT DLRTVEKELTYEKFVEWTRL DMMDEEEVEVSLPRFKLEES YDMESVLRNLGMTDAFELGK A |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 180-300 of human SERPINB6 (NP_004559.4). |
| Tissue Specificity | Expressed in keratinocytes (at protein level). Highest levels in skeletal muscle. Also found in placenta, cardiac muscle, lung, liver, kidney and pancreas. Expressed in the inner ear hair cells. Expressed abundantly by normal mast cells in different tissues and by mast cells in mastocytoma lesions. |
| Function | May be involved in the regulation of serine proteinases present in the brain or extravasated from the blood. Inhibitor of cathepsin G, kallikrein-8 and thrombin. May play an important role in the inner ear in the protection against leakage of lysosomal content during stress and loss of this protection results in cell death and sensorineural hearing loss. |
| Protein Name | Serpin B6Cytoplasmic AntiproteinaseCapPeptidase Inhibitor 6Pi-6Placental Thrombin Inhibitor |
| Database Links | Reactome: R-HSA-6798695Reactome: R-HSA-75205 |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Serpin B6 antibodyAnti-Cytoplasmic Antiproteinase antibodyAnti-Cap antibodyAnti-Peptidase Inhibitor 6 antibodyAnti-Pi-6 antibodyAnti-Placental Thrombin Inhibitor antibodyAnti-SERPINB6 antibodyAnti-PI6 antibodyAnti-PTI antibody |
Information sourced from Uniprot.org
