Anti-SERPINB3 antibody (2-390) (STJ27371)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal SERPINB3 (2-390) antibody for use in WB, IF, ICC and ELISA in human and mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IF/ICC/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:1000IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | SERPINB3 |
| Gene ID | 6317 |
| Uniprot ID | SPB3_HUMAN |
| Immunogen Region | 2-390 |
| Immunogen Sequence | NSLSEANTKFMFDLFQQFRK SKENNIFYSPISITSALGMV LLGAKDNTAQQIKKVLHFDQ VTENTTGKAATYHVDRSGNV HHQFQKLLTEFNKSTDAYEL KIANKLFGEKTYLFLQEYLD AIKKFYQTSVESVDFANAPE ESRKKINSWVESQTNEKIKN LIPEGNIGSNTTLVLVNAIY FKGQWEKKFNKEDTKEEKFW PNKNTYKSIQMMRQYTSFHF ASLEDVQAKVLEIPYKGKD |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 2-390 of human SSCA1/SerpinB3 (NP_008850.1). |
Additional Info
| Tissue Specificity | Squamous cells. Expressed in some hepatocellular carcinoma (at protein level). |
| Function | May act as a papain-like cysteine protease inhibitor to modulate the host immune response against tumor cells. Also functions as an inhibitor of UV-induced apoptosis via suppression of the activity of c-Jun NH(2)-terminal kinase (JNK1). |
| Protein Name | Serpin B3Protein T4-ASquamous Cell Carcinoma Antigen 1Scca-1 |
| Database Links | Reactome: R-HSA-6798695 |
| Cellular Localisation | CytoplasmSeems To Also Be Secreted In Plasma By Cancerous Cells But At A Low Level |
| Alternative Antibody Names | Anti-Serpin B3 antibodyAnti-Protein T4-A antibodyAnti-Squamous Cell Carcinoma Antigen 1 antibodyAnti-Scca-1 antibodyAnti-SERPINB3 antibodyAnti-SCCA antibodyAnti-SCCA1 antibody |
Information sourced from Uniprot.org