| Host: | Rabbit |
| Applications: | WB/IF/ICC/ELISA |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:1000IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | SERPINB3 |
| Gene ID: | 6317 |
| Uniprot ID: | SPB3_HUMAN |
| Immunogen Region: | 2-390 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 2-390 of human SSCA1/SerpinB3 (NP_008850.1). |
| Immunogen Sequence: | NSLSEANTKFMFDLFQQFRK SKENNIFYSPISITSALGMV LLGAKDNTAQQIKKVLHFDQ VTENTTGKAATYHVDRSGNV HHQFQKLLTEFNKSTDAYEL KIANKLFGEKTYLFLQEYLD AIKKFYQTSVESVDFANAPE ESRKKINSWVESQTNEKIKN LIPEGNIGSNTTLVLVNAIY FKGQWEKKFNKEDTKEEKFW PNKNTYKSIQMMRQYTSFHF ASLEDVQAKVLEIPYKGKD |
| Tissue Specificity | Squamous cells. Expressed in some hepatocellular carcinoma (at protein level). |
| Function | May act as a papain-like cysteine protease inhibitor to modulate the host immune response against tumor cells. Also functions as an inhibitor of UV-induced apoptosis via suppression of the activity of c-Jun NH(2)-terminal kinase (JNK1). |
| Protein Name | Serpin B3Protein T4-ASquamous Cell Carcinoma Antigen 1Scca-1 |
| Database Links | Reactome: R-HSA-6798695 |
| Cellular Localisation | CytoplasmSeems To Also Be Secreted In Plasma By Cancerous Cells But At A Low Level |
| Alternative Antibody Names | Anti-Serpin B3 antibodyAnti-Protein T4-A antibodyAnti-Squamous Cell Carcinoma Antigen 1 antibodyAnti-Scca-1 antibodyAnti-SERPINB3 antibodyAnti-SCCA antibodyAnti-SCCA1 antibody |
Information sourced from Uniprot.org