| Host: |
Goat |
| Applications: |
Pep-ELISA/WB/IHC |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Goat polyclonal antibody anti-SERPINB1 (Internal) is suitable for use in ELISA, Western Blot and Immunohistochemistry research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Purification: |
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Concentration: |
0.5 mg/mL |
| Dilution Range: |
WB-1-3µg/mlIHC-5µg/mlELISA-antibody detection limit dilution 1:128000. |
| Storage Instruction: |
Store at-20°C on receipt and minimise freeze-thaw cycles. |
| Gene Symbol: |
SERPINB1 |
| Gene ID: |
1992 |
| Uniprot ID: |
ILEU_HUMAN |
| Immunogen Region: |
Internal |
| Accession Number: |
NP_109591.1 |
| Immunogen Sequence: |
EVHSRFQSLNADINKR |
| Function | Neutrophil serine protease inhibitor that plays an essential role in the regulation of the innate immune response, inflammation and cellular homeostasis. Acts primarily to protect the cell from proteases released in the cytoplasm during stress or infection. These proteases are important in killing microbes but when released from granules, these potent enzymes also destroy host proteins and contribute to mortality. Regulates the activity of the neutrophil proteases elastase, cathepsin G, proteinase-3, chymase, chymotrypsin, and kallikrein-3. Acts also as a potent intracellular inhibitor of GZMH by directly blocking its proteolytic activity. During inflammation, limits the activity of inflammatory caspases CASP1, CASP4 and CASP5 by suppressing their caspase-recruitment domain (CARD) oligomerization and enzymatic activation. When secreted, promotes the proliferation of beta-cells via its protease inhibitory function. |
| Protein Name | Leukocyte Elastase InhibitorLeiMonocyte/Neutrophil Elastase InhibitorEiM/NeiPeptidase Inhibitor 2Pi-2Serpin B1 |
| Database Links | Reactome: R-HSA-6798695 |
| Cellular Localisation | SecretedCytoplasmCytolytic GranuleEarly Endosome |
| Alternative Antibody Names | Anti-Leukocyte Elastase Inhibitor antibodyAnti-Lei antibodyAnti-Monocyte/Neutrophil Elastase Inhibitor antibodyAnti-Ei antibodyAnti-M/Nei antibodyAnti-Peptidase Inhibitor 2 antibodyAnti-Pi-2 antibodyAnti-Serpin B1 antibodyAnti-SERPINB1 antibodyAnti-ELANH2 antibodyAnti-MNEI antibodyAnti-PI2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
